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RNF6 ring finger protein 6 [ Homo sapiens (human) ]

Gene ID: 6049, updated on 2-Nov-2024

Summary

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Official Symbol
RNF6provided by HGNC
Official Full Name
ring finger protein 6provided by HGNC
Primary source
HGNC:HGNC:10069
See related
Ensembl:ENSG00000127870 MIM:604242; AllianceGenome:HGNC:10069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.5), brain (RPKM 11.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See RNF6 in Genome Data Viewer
Location:
13q12.13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (26132115..26223085, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (25346027..25436863, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (26706253..26796508, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 415 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:26650935-26651149 Neighboring gene NANOG hESC enhancer GRCh37_chr13:26673008-26673509 Neighboring gene ATPase phospholipid transporting 8A2 pseudogene 3 Neighboring gene PRUNE1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7491 Neighboring gene Sharpr-MPRA regulatory region 3220 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:26795223-26796104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:26796105-26796986 Neighboring gene THAP domain containing 12 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5186 Neighboring gene cyclin dependent kinase 8 Neighboring gene NANOG hESC enhancer GRCh37_chr13:26953049-26953564

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12. Macdonald DH, et al. Genomics, 1999 May 15. PMID 10331950
  2. E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells. Sun W, et al. Clin Immunol, 2022 Sep. PMID 35973638
  3. Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development. Zhu L, et al. Sci China C Life Sci, 2008 Apr. PMID 18368307
  4. RING-Finger Protein 6 promotes Drug Resistance in Retinoblastoma via JAK2/STAT3 Signaling Pathway. Chai Y, et al. Pathol Oncol Res, 2022. PMID 35369571, Free PMC Article
  5. RNF6 serves as a diagnostic hallmark of non-alcoholic fatty liver disease with hepatocellular carcinoma: a clinical research. Jin ZD, et al. Eur Rev Med Pharmacol Sci, 2020 Nov. PMID 33215420

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Non-adherent culture method affects the proliferation and apoptosis of mesenchymal stem cells through inhibiting LINC00707 to promote RNF6-mediated QKI ubiquitination.
    Title: Non-adherent culture method affects the proliferation and apoptosis of mesenchymal stem cells through inhibiting LINC00707 to promote RNF6-mediated QKI ubiquitination.
  2. E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
    Title: E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
  3. Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling.
    Title: Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling.
  4. Ring finger protein 6 enhances chemo-resistance by transcriptionally activating proliferating cell nuclear antigen expression and attenuating DNA damage in lung adenocarcinoma.
    Title: Ring finger protein 6 enhances chemo-resistance by transcriptionally activating proliferating cell nuclear antigen expression and attenuating DNA damage in lung adenocarcinoma.
  5. RING-Finger Protein 6 promotes Drug Resistance in Retinoblastoma via JAK2/STAT3 Signaling Pathway.
    Title: RING-Finger Protein 6 promotes Drug Resistance in Retinoblastoma via JAK2/STAT3 Signaling Pathway.
  6. RNF6 promotes colorectal cancer invasion and migration via the Wnt/beta-catenin pathway by inhibiting GSK3beta activity.
    Title: RNF6 promotes colorectal cancer invasion and migration via the Wnt/β-catenin pathway by inhibiting GSK3β activity.
  7. RING-finger protein 6 promotes colorectal tumorigenesis by transcriptionally activating SF3B2.
    Title: RING-finger protein 6 promotes colorectal tumorigenesis by transcriptionally activating SF3B2.
  8. Gene commander in the trash heap: Transcriptional regulation and ubiquitination modification mediated by RNF6 in carcinogenesis.
    Title: Gene commander in the trash heap: Transcriptional regulation and ubiquitination modification mediated by RNF6 in carcinogenesis.
  9. RNF6 serves as a diagnostic hallmark of non-alcoholic fatty liver disease with hepatocellular carcinoma: a clinical research.
    Title: RNF6 serves as a diagnostic hallmark of non-alcoholic fatty liver disease with hepatocellular carcinoma: a clinical research.
  10. RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination.
    Title: RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Malignant tumor of esophagus
MedGen: C0546837 OMIM: 133239 GeneReviews: Not available
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EBI GWAS Catalog

Description
A comprehensive genetic association study of Alzheimer disease in African Americans.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686P0776

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon extension IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K27-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K6-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF6
Names
RING-H2 protein RNF-6
RING-type E3 ubiquitin transferase RNF6
ring finger protein (C3H2C3 type) 6
NP_005968.1
NP_898864.1
NP_898865.1
NP_898866.1
XP_005266542.1
XP_005266543.1
XP_011533479.1
XP_011533480.1
XP_016876174.1
XP_016876175.1
XP_016876176.1
XP_024305158.1
XP_024305159.1
XP_024305160.1
XP_047286450.1
XP_047286451.1
XP_047286452.1
XP_047286454.1
XP_047286455.1
XP_047286456.1
XP_054230762.1
XP_054230763.1
XP_054230764.1
XP_054230765.1
XP_054230766.1
XP_054230767.1
XP_054230768.1
XP_054230769.1
XP_054230770.1
XP_054230771.1
XP_054230772.1
XP_054230773.1
XP_054230774.1
XP_054230775.1
XP_054230776.1
XP_054230777.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017042.2 RefSeqGene

    Range
    5058..14597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005977.4 → NP_005968.1  E3 ubiquitin-protein ligase RNF6 isoform 1

    See identical proteins and their annotated locations for NP_005968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AL138966
    Consensus CDS
    CCDS9316.1
    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2, Q68DX6
    Related
    ENSP00000371000.4, ENST00000381588.9
    Conserved Domains (1) summary
    cd16673
    Location:630 → 674
    RING-H2_RNF6; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase RNF6 and similar proteins

  2. NM_183043.3 → NP_898864.1  E3 ubiquitin-protein ligase RNF6 isoform 1

    See identical proteins and their annotated locations for NP_898864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, as compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AJ010347, AK293272, AL138966, DC310579
    Consensus CDS
    CCDS9316.1
    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2, Q68DX6
    Related
    ENSP00000342121.3, ENST00000346166.7
    Conserved Domains (1) summary
    cd16673
    Location:630 → 674
    RING-H2_RNF6; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase RNF6 and similar proteins

  3. NM_183044.3 → NP_898865.1  E3 ubiquitin-protein ligase RNF6 isoform 1

    See identical proteins and their annotated locations for NP_898865.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, as compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AL138966, AY009109, BP310130, BU633523, DB062601
    Consensus CDS
    CCDS9316.1
    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2, Q68DX6
    Related
    ENSP00000370982.3, ENST00000381570.7
    Conserved Domains (1) summary
    cd16673
    Location:630 → 674
    RING-H2_RNF6; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase RNF6 and similar proteins

  4. NM_183045.1 → NP_898866.1  E3 ubiquitin-protein ligase RNF6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF293342, BI461269
    UniProtKB/Swiss-Prot
    Q9Y252
    Related
    ENST00000468480.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    26132115..26223085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430500.1 → XP_047286456.1  E3 ubiquitin-protein ligase RNF6 isoform X4

  2. XM_047430498.1 → XP_047286454.1  E3 ubiquitin-protein ligase RNF6 isoform X4

  3. XM_047430499.1 → XP_047286455.1  E3 ubiquitin-protein ligase RNF6 isoform X4

  4. XM_011535178.3 → XP_011533480.1  E3 ubiquitin-protein ligase RNF6 isoform X4

    See identical proteins and their annotated locations for XP_011533480.1

    UniProtKB/Swiss-Prot
    Q9Y252

  5. XM_024449392.2 → XP_024305160.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  6. XM_024449390.2 → XP_024305158.1  E3 ubiquitin-protein ligase RNF6 isoform X1

    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2, Q68DX6
    Conserved Domains (1) summary
    cd16673
    Location:630 → 674
    RING-H2_RNF6; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase RNF6 and similar proteins

  7. XM_017020686.2 → XP_016876175.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  8. XM_047430495.1 → XP_047286451.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  9. XM_005266485.4 → XP_005266542.1  E3 ubiquitin-protein ligase RNF6 isoform X1

    See identical proteins and their annotated locations for XP_005266542.1

    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2, Q68DX6
    Conserved Domains (1) summary
    cd16673
    Location:630 → 674
    RING-H2_RNF6; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase RNF6 and similar proteins

  10. XM_047430496.1 → XP_047286452.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  11. XM_011535177.4 → XP_011533479.1  E3 ubiquitin-protein ligase RNF6 isoform X1

    See identical proteins and their annotated locations for XP_011533479.1

    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2, Q68DX6
    Conserved Domains (1) summary
    cd16673
    Location:630 → 674
    RING-H2_RNF6; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase RNF6 and similar proteins

  12. XM_017020685.3 → XP_016876174.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  13. XM_017020687.2 → XP_016876176.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  14. XM_005266486.3 → XP_005266543.1  E3 ubiquitin-protein ligase RNF6 isoform X1

    See identical proteins and their annotated locations for XP_005266543.1

    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2, Q68DX6
    Conserved Domains (1) summary
    cd16673
    Location:630 → 674
    RING-H2_RNF6; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase RNF6 and similar proteins

  15. XM_024449391.2 → XP_024305159.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  16. XM_047430494.1 → XP_047286450.1  E3 ubiquitin-protein ligase RNF6 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    25346027..25436863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374802.1 → XP_054230777.1  E3 ubiquitin-protein ligase RNF6 isoform X4

  2. XM_054374800.1 → XP_054230775.1  E3 ubiquitin-protein ligase RNF6 isoform X4

  3. XM_054374801.1 → XP_054230776.1  E3 ubiquitin-protein ligase RNF6 isoform X4

  4. XM_054374799.1 → XP_054230774.1  E3 ubiquitin-protein ligase RNF6 isoform X4

  5. XM_054374797.1 → XP_054230772.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  6. XM_054374794.1 → XP_054230769.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  7. XM_054374796.1 → XP_054230771.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  8. XM_054374793.1 → XP_054230768.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  9. XM_054374792.1 → XP_054230767.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  10. XM_054374795.1 → XP_054230770.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  11. XM_054374798.1 → XP_054230773.1  E3 ubiquitin-protein ligase RNF6 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4G9

  12. XM_054374791.1 → XP_054230766.1  E3 ubiquitin-protein ligase RNF6 isoform X2

  13. XM_054374790.1 → XP_054230765.1  E3 ubiquitin-protein ligase RNF6 isoform X1

    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2

  14. XM_054374787.1 → XP_054230762.1  E3 ubiquitin-protein ligase RNF6 isoform X1

    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2

  15. XM_054374788.1 → XP_054230763.1  E3 ubiquitin-protein ligase RNF6 isoform X1

    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2

  16. XM_054374789.1 → XP_054230764.1  E3 ubiquitin-protein ligase RNF6 isoform X1

    UniProtKB/Swiss-Prot
    B4DDP0, Q5W0H0, Q9BZP5, Q9UF41, Q9Y252
    UniProtKB/TrEMBL
    A0A024RDP2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y252.1 GenPept UniProtKB/Swiss-Prot:Q9Y252

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