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Wtap WT1 associating protein [ Mus musculus (house mouse) ]

Gene ID: 60532, updated on 2-Nov-2024

Summary

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Official Symbol
Wtapprovided by MGI
Official Full Name
WT1 associating proteinprovided by MGI
Primary source
MGI:MGI:1926395
See related
Ensembl:ENSMUSG00000060475 AllianceGenome:MGI:1926395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810408K05Rik; 9430038B09Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in mRNA modification; mRNA processing; and regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasm and nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in several structures, including early conceptus; embryo mesoderm; hemolymphoid system gland; hindlimb; and jaw epithelium. Orthologous to human WTAP (WT1 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.9), CNS E18 (RPKM 10.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wtap in Genome Data Viewer
Location:
17 A1; 17 8.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13185686..13211430, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12966799..12992543, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene acetyl-Coenzyme A acetyltransferase 2 Neighboring gene predicted gene 15946 Neighboring gene STARR-seq mESC enhancer starr_41863 Neighboring gene STARR-seq mESC enhancer starr_41864 Neighboring gene STARR-positive B cell enhancer ABC_E7488 Neighboring gene STARR-positive B cell enhancer ABC_E10934 Neighboring gene STARR-positive B cell enhancer ABC_E10935 Neighboring gene superoxide dismutase 2, mitochondrial Neighboring gene predicted gene, 36117

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization. Bai Y, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Aug. PMID 37019244
  2. The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis. Li Y, et al. Front Immunol, 2024. PMID 39081311, Free PMC Article
  3. WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche. Jia GX, et al. Stem Cell Reports, 2020 Oct 13. PMID 33053361, Free PMC Article
  4. WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma. Zhang Y, et al. Mamm Genome, 2022 Dec. PMID 36173464
  5. Loss of Wtap results in cerebellar ataxia and degeneration of Purkinje cells. Yang Y, et al. J Genet Genomics, 2022 Sep. PMID 35304325

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.
    Title: The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.
  2. Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.
    Title: Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.
  3. WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
    Title: WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
  4. WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.
    Title: WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.
  5. Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice.
    Title: Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice.
  6. WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner.
    Title: WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner.
  7. WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.
    Title: WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.
  8. WTAP-mediated m[6]A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis.
    Title: WTAP-mediated m(6)A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis.
  9. N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis.
    Title: N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis.
  10. WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma.
    Title: WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
pre-mRNA-splicing regulator WTAP
Names
WT1-associated protein
Wilms tumour 1-associating protein
Wilms' tumour 1-associating protein
female-lethal(2)D homolog
wilms tumor 1-associating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113532.1 → NP_001107004.1  pre-mRNA-splicing regulator WTAP isoform b

    See identical proteins and their annotated locations for NP_001107004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.
    Source sequence(s)
    AK031965, AK041341, BC093504, BY016042
    Consensus CDS
    CCDS49949.1
    UniProtKB/TrEMBL
    F7CCI4
    Related
    ENSMUSP00000123961.2, ENSMUST00000159986.8
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 150
    Wtap; WTAP/Mum2p family

  2. NM_001113533.1 → NP_001107005.1  pre-mRNA-splicing regulator WTAP isoform a

    See identical proteins and their annotated locations for NP_001107005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL589878
    Consensus CDS
    CCDS49950.1
    UniProtKB/Swiss-Prot
    Q3U120, Q566J5, Q9ER69
    UniProtKB/TrEMBL
    E0CYH0
    Related
    ENSMUSP00000007007.8, ENSMUST00000007007.14
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 222
    Wtap; WTAP/Mum2p family

  3. NM_001379058.1 → NP_001365987.1  pre-mRNA-splicing regulator WTAP isoform a

    Status: VALIDATED

    Source sequence(s)
    AL589878
    UniProtKB/Swiss-Prot
    Q3U120, Q566J5, Q9ER69
    UniProtKB/TrEMBL
    E0CYH0
    Related
    ENSMUSP00000124205.2, ENSMUST00000159551.8
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 222
    Wtap; WTAP/Mum2p family

  4. NM_175394.2 → NP_780603.1  pre-mRNA-splicing regulator WTAP isoform b

    See identical proteins and their annotated locations for NP_780603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 5' UTR exon and lacks two exons, and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.
    Source sequence(s)
    AK031965, AK041341, AK076111
    Consensus CDS
    CCDS49949.1
    UniProtKB/TrEMBL
    F7CCI4
    Related
    ENSMUSP00000124138.2, ENSMUST00000160781.8
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 150
    Wtap; WTAP/Mum2p family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13185686..13211430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER69.3 GenPept UniProtKB/Swiss-Prot:Q9ER69

Gene LinkOut

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