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Stx6 syntaxin 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60562, updated on 2-May-2024

Summary

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Official Symbol
Stx6provided by RGD
Official Full Name
syntaxin 6provided by RGD
Primary source
RGD:61915
See related
Ensembl:ENSRNOG00000003402 AllianceGenome:RGD:61915
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in synaptic vesicle to endosome fusion. Located in synaptic vesicle and trans-Golgi network membrane. Is integral component of membrane. Is integral component of synaptic vesicle membrane. Orthologous to human STX6 (syntaxin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 184.0), Thymus (RPKM 159.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stx6 in Genome Data Viewer
Location:
13q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (69882647..69928895)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (67332329..67378580)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (72804218..72850757)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene major histocompatibility complex, class I-related Neighboring gene KIAA1614 homolog Neighboring gene xenotropic and polytropic retrovirus receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Syntaxin 6 regulates nerve growth factor-dependent neurite outgrowth. Kabayama H, et al. Neurosci Lett, 2008 May 16. PMID 18406529
  2. Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells. Kuliawat R, et al. Mol Biol Cell, 2004 Apr. PMID 14742717, Free PMC Article
  3. Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog. Misura KM, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12082176, Free PMC Article
  4. Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells. Ahras M, et al. J Cell Biol, 2006 Apr 24. PMID 16618809, Free PMC Article
  5. A new syntaxin family member implicated in targeting of intracellular transport vesicles. Bock JB, et al. J Biol Chem, 1996 Jul 26. PMID 8663448

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syntaxin 6 regulates nerve growth factor-dependent neurite outgrowth.
    Title: Syntaxin 6 regulates nerve growth factor-dependent neurite outgrowth.
  2. syntaxin 6 is involved in a membrane-trafficking step that sequesters Glut4 away from traffic destined for the plasma membrane
    Title: Syntaxin 6 regulates Glut4 trafficking in 3T3-L1 adipocytes.
  3. Syntaxin-6 has a role in secretory and endocytic pathways in pancreatic beta cells
    Title: Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells.
  4. Depletion of MARCH-II by small interfering RNA perturbed the TGN localization of syntaxin 6 and TGN38/46
    Title: MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93348

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytic recycling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle to endosome fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle to endosome fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton HDA PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
syntaxin-6
Names
Syn6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031665.2 → NP_113853.1  syntaxin-6

    See identical proteins and their annotated locations for NP_113853.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081769
    UniProtKB/Swiss-Prot
    Q63635
    UniProtKB/TrEMBL
    A6ICY5
    Related
    ENSRNOP00000080858.1, ENSRNOT00000099649.1
    Conserved Domains (2) summary
    cd15851
    Location:166 → 231
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
    cd21447
    Location:5 → 107
    SNARE_NTD_STX6; N-terminal domain of syntaxin-6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    69882647..69928895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63635.1 GenPept UniProtKB/Swiss-Prot:Q63635

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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