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Syt10 synaptotagmin 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60567, updated on 18-Sep-2024

Summary

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Official Symbol
Syt10provided by RGD
Official Full Name
synaptotagmin 10provided by RGD
Primary source
RGD:62041
See related
EnsemblRapid:ENSRNOG00000014296 AllianceGenome:RGD:62041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including phospholipid binding activity; protein dimerization activity; and syntaxin binding activity. Predicted to be involved in several processes, including cellular response to calcium ion; regulation of secretion by cell; and sensory perception of smell. Predicted to be located in synapse and transport vesicle membrane. Predicted to be integral component of membrane. Predicted to be active in exocytic vesicle and plasma membrane. Biomarker of visual epilepsy. Orthologous to human SYT10 (synaptotagmin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 43.1), Kidney (RPKM 9.4) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Syt10 in Genome Data Viewer
Location:
7q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122737301..122800462, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120857698..120920863, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130769039..130827030, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 2 Neighboring gene uncharacterized LOC120093828 Neighboring gene uncharacterized LOC120093709 Neighboring gene ALG10, alpha-1,2-glucosyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel seizure-induced synaptotagmin gene identified by differential display. Babity JM, et al. Proc Natl Acad Sci U S A, 1997 Mar 18. PMID 9122248, Free PMC Article
  2. Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cao P, et al. Cell, 2011 Apr 15. PMID 21496647, Free PMC Article
  3. A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoforms. Fukuda M, et al. J Biol Chem, 1999 Oct 29. PMID 10531344
  4. Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. Tucker WC, et al. J Cell Biol, 2003 Jul 21. PMID 12860971, Free PMC Article
  5. Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. Fukuda M, et al. J Biol Chem, 1999 Oct 29. PMID 10531343

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in presynaptic dense core vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of smell ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in synaptic vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in exocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
synaptotagmin-10
Names
synaptotagmin X
sytX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031666.3 → NP_113854.1  synaptotagmin-10

    See identical proteins and their annotated locations for NP_113854.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    O08625, Q925B8
    UniProtKB/TrEMBL
    A6K7P3, Q1W5B9
    Related
    ENSRNOP00000109467.1, ENSRNOT00000172684.1
    Conserved Domains (2) summary
    cd08385
    Location:231 → 356
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:365 → 498
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    122737301..122800462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08625.2 GenPept UniProtKB/Swiss-Prot:O08625

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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