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Mybbp1a MYB binding protein 1a [ Rattus norvegicus (Norway rat) ]

Gene ID: 60571, updated on 28-Oct-2024

Summary

Official Symbol
Mybbp1aprovided by RGD
Official Full Name
MYB binding protein 1aprovided by RGD
Primary source
RGD:62062
See related
EnsemblRapid:ENSRNOG00000015236 AllianceGenome:RGD:62062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DBP
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; positive regulation of anoikis; and regulation of gene expression. Predicted to act upstream of with a negative effect on regulation of G1 to G0 transition. Predicted to act upstream of or within respiratory electron transport chain. Predicted to be located in cytoplasm and nucleus. Predicted to be part of B-WICH complex and NLS-dependent protein nuclear import complex. Predicted to be active in nucleolus. Orthologous to human MYBBP1A (MYB binding protein 1a). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Muscle (RPKM 218.6), Adrenal (RPKM 217.7) and 9 other tissues See more
Orthologs
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Genomic context

See Mybbp1a in Genome Data Viewer
Location:
10q24
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (57555458..57565819)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57056897..57067258)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59000400..59010794)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480820 Neighboring gene smoothelin-like 2 Neighboring gene gamma-glutamyl transferase 6 Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate Neighboring gene SPNS lysolipid transporter 3, sphingosine-1-phosphate

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables E-box binding IEA
Inferred from Electronic Annotation
more info
 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of anoikis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G1 to G0 transition IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_negative_effect regulation of G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of B-WICH complex IEA
Inferred from Electronic Annotation
more info
 
part_of B-WICH complex ISO
Inferred from Sequence Orthology
more info
 
part_of NLS-dependent protein nuclear import complex IEA
Inferred from Electronic Annotation
more info
 
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
 
part_of NLS-dependent protein nuclear import complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
myb-binding protein 1A
Names
MYB binding protein (P160) 1a
PAR-interacting protein
PIP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031668.2NP_113856.2  myb-binding protein 1A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    O35821
    UniProtKB/TrEMBL
    A6HGF6
    Related
    ENSRNOP00000021134.2, ENSRNOT00000021134.5
    Conserved Domains (2) summary
    pfam04931
    Location:70833
    DNA_pol_phi; DNA polymerase phi
    NF033756
    Location:11681255
    gliding_GltC; adventurous gliding motility protein GltC

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    57555458..57565819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)