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Unc5a unc-5 netrin receptor A [ Rattus norvegicus (Norway rat) ]

Gene ID: 60629, updated on 2-Nov-2024

Summary

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Official Symbol
Unc5aprovided by RGD
Official Full Name
unc-5 netrin receptor Aprovided by RGD
Primary source
RGD:621755
See related
EnsemblRapid:ENSRNOG00000059840 AllianceGenome:RGD:621755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Unc5h1
Summary
Enables netrin receptor activity. Involved in axon guidance and netrin-activated signaling pathway. Located in neuron projection membrane and neuronal cell body membrane. Orthologous to human UNC5A (unc-5 netrin receptor A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 33.6), Adrenal (RPKM 7.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Unc5a in Genome Data Viewer
Location:
17p14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9620005..9675794, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9614841..9670558, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10152949..10208599, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 346 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene hexokinase 3 Neighboring gene uncharacterized LOC120097834 Neighboring gene tetraspanin 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth. Picard M, et al. Cell Signal, 2009 Dec. PMID 19755150
  2. Expression patterns of the netrin receptor UNC5H1 among developing motor neurons in the embryonic rat hindbrain. Barrett C, et al. Mech Dev, 2001 Aug. PMID 11472849
  3. Schwann cells direct peripheral nerve regeneration through the Netrin-1 receptors, DCC and Unc5H2. Webber CA, et al. Glia, 2011 Oct. PMID 21656855
  4. Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism. Williams ME, et al. J Neurosci, 2003 Dec 10. PMID 14672991, Free PMC Article
  5. The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality. Muramatsu R, et al. Brain, 2010 Jan. PMID 19858080

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unc5H Receptors have Prominent Expression in Adult Schwann cells.
    Title: Schwann cells direct peripheral nerve regeneration through the Netrin-1 receptors, DCC and Unc5H2.
  2. Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems.
    Title: Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.
  3. Hyperactivity increases the surface expression of uncoordinated-5A (Unc5a), which is suppressed by blocking cyclic adenosine monophosphate signaling.
    Title: The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality.
  4. Surface expression of the netrin receptor UNC5H1 is regulated by Protein interacting with C kinase-1 and protein kinase C in neurons.
    Title: Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism.
  5. UNC5H1 expression colocalised with a number of cranial motor neuron subpopulations from embryonic day 11 (E11) to E14.
    Title: Expression patterns of the netrin receptor UNC5H1 among developing motor neurons in the embryonic rat hindbrain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables netrin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables netrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anterior/posterior axon guidance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anterior/posterior axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in axon guidance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
  
involved_in netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in netrin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in neuronal cell body membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
netrin receptor UNC5A
Names
protein unc-5 homolog 1
protein unc-5 homolog A
transmembrane receptor Unc5H1
unc-5 homolog 1
unc-5 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022206.2 → NP_071542.2  netrin receptor UNC5A precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I5YBB0
    Related
    ENSRNOP00000076444.2, ENSRNOT00000107999.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    9620005..9675794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771505.3 → XP_008769727.1  netrin receptor UNC5A isoform X1

    UniProtKB/Swiss-Prot
    O08721
    UniProtKB/TrEMBL
    A0A0G2JZN2
    Related
    ENSRNOP00000071115.3, ENSRNOT00000087397.3
    Conserved Domains (5) summary
    smart00218
    Location:439 → 542
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:254 → 293
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151 → 239
    I-set; Immunoglobulin I-set domain
    cd08800
    Location:755 → 838
    Death_UNC5A; Death domain found in Uncoordinated-5A
    cl11960
    Location:153 → 239
    Ig; Immunoglobulin domain

RNA

  1. XR_005495326.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08721.1 GenPept UniProtKB/Swiss-Prot:O08721

Gene LinkOut

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