Kifbp kinesin family binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kifbpprovided by RGD
Official Full Name: kinesin family binding proteinprovided by RGD
Primary source: RGD:1593126
See related: EnsemblRapid:ENSRNOG00000000395 AllianceGenome:RGD:1593126
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kbp; Kif1bp
Summary: Predicted to enable kinesin binding activity and protein sequestering activity. Predicted to be involved in microtubule cytoskeleton organization; mitochondrion transport along microtubule; and plasma membrane bounded cell projection organization. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in Goldberg-Shprintzen syndrome. Orthologous to human KIFBP (kinesin family binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 225.3), Kidney (RPKM 130.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (31055625..31075232, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30512899..30532504, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (32191731..32211295, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KBP-depleted PC12 cells were defective in nerve growth factor-induced differentiation and neurite outgrowth, suggesting that KBP is required for cell differentiation and neurite development.
Title: KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	IEA Inferred from Electronic Annotation more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in central nervous system projection neuron axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion transport along microtubule	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion transport along microtubule	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in transport along microtubule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: KIF-binding protein

Names: KIF1 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031627.1 → NP_001026797.1 KIF-binding protein

See identical proteins and their annotated locations for NP_001026797.1

Status: VALIDATED

Source sequence(s)

BC060521, BC098692

UniProtKB/Swiss-Prot

Q4G074

UniProtKB/TrEMBL

A6K453, G3V614

Related

ENSRNOP00000000444.6, ENSRNOT00000000444.9

Conserved Domains (1) summary

pfam12309
Location:243 → 609

KBP_C; KIF-1 binding protein C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

31055625..31075232 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099049.2 → XP_038954977.1 KIF-binding protein isoform X2

UniProtKB/TrEMBL

A0A8I5ZUA6

Related

ENSRNOP00000082090.1, ENSRNOT00000103307.2

Conserved Domains (1) summary

pfam12309
Location:243 → 293

KBP_C; KIF-1 binding protein C terminal
XM_063279488.1 → XP_063135558.1 KIF-binding protein isoform X1