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Defa7 defensin alpha 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 613222, updated on 17-Aug-2024

Summary

Symbol
Defa7provided by RGD
Full Name
defensin alpha 7provided by RGD
Primary source
RGD:1560529
See related
AllianceGenome:RGD:1560529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Restricted expression toward (RPKM 102.3) See more
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Genomic context

Location:
16q12.5
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77121608..77133013, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70419152..70430555, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75414786..75415555, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene defensin alpha-like 1, pseudogene 1 Neighboring gene defensin alpha 6 Neighboring gene defensin alpha 8 Neighboring gene defensin alpha 5, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033075.2NP_001028247.1  alpha-defensin 7 precursor

    See identical proteins and their annotated locations for NP_001028247.1

    Status: VALIDATED

    Source sequence(s)
    AY623751, JAXUCZ010000016
    UniProtKB/TrEMBL
    F1LQB7, Q4JEI7
    Conserved Domains (2) summary
    pfam00323
    Location:6795
    Defensin_1; Mammalian defensin
    pfam00879
    Location:1853
    Defensin_propep; Defensin propeptide

RNA

  1. NR_172012.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant (1, coding) but represents the allele present on the mRatBN7.2 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    JAXUCZ010000016

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    77121608..77133013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)