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RPL26 ribosomal protein L26 [ Homo sapiens (human) ]

Gene ID: 6154, updated on 7-Apr-2024

Summary

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Official Symbol
RPL26provided by HGNC
Official Full Name
ribosomal protein L26provided by HGNC
Primary source
HGNC:HGNC:10327
See related
Ensembl:ENSG00000161970 MIM:603704; AllianceGenome:HGNC:10327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L26; uL24; DBA11
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in ovary (RPKM 654.6), bone marrow (RPKM 461.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8377516..8383193, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8283737..8289839, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8280834..8286511, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8257795-8258364 Neighboring gene uncharacterized LOC100128288 Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8279661-8280212 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8285969-8286686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8286687-8287404 Neighboring gene KRAB-A domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 12124 Neighboring gene ring finger protein 222 Neighboring gene Sharpr-MPRA regulatory regions 4336 and 10869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8184 Neighboring gene nudE neurodevelopment protein 1 like 1 Neighboring gene MPRA-validated peak2716 silencer Neighboring gene MPRA-validated peak2717 silencer Neighboring gene myosin heavy chain 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A tale of two ends. Towers CG, et al. Cell Cycle, 2016 Jun 17. PMID 27101085, Free PMC Article
  2. Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Gazda HT, et al. Hum Mutat, 2012 Jul. PMID 22431104, Free PMC Article
  3. p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability. Zhang M, et al. Oncotarget, 2016 Nov 29. PMID 27825141, Free PMC Article
  4. Investigating the cellular distribution and interactions of HIV-1 nucleocapsid protein by quantitative fluorescence microscopy. Anton H, et al. PLoS One, 2015. PMID 25723396, Free PMC Article
  5. Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells. Li C, et al. Mol Cell Biochem, 2012 Nov. PMID 22868929

See all (165) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ionizing radiation (IR) inhibits the activity of SMG1, a phosphoinositide-3-kinase-like kinase family member, reducing the binding of SMG1 to a specific region near exon 9 of p53 precursor mRNA and promoting the binding of ribosomal protein L26 (RPL26) to p53 pre-mRNA
    Title: Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.
  2. In colorectal tumor cells RPL26 regulates p73 expression via two distinct mechanisms: protein stability and mRNA translation.
    Title: p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability.
  3. Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26.
    Title: The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p.
  4. The results showed that knockdown of RPL26 or RPL29 expression significantly suppressed cell proliferation, induced cell arrest at G0/G1 phase and enhanced cell apoptosis
    Title: Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells.
  5. Northern Blot Together with RPL5, RPL11, and RPS7, RPL26 is the fourth RP regulating p53 activity that is linked to diamond-blackfan anemia.
    Title: Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia.
  6. suggest a model in which the base pairings in the p53 UTR interaction regions are critical for both translational repression and stress induction of p53 by NCL and RPL26
    Title: Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA.
  7. Mdm2 binds L26 and drives its polyubiquitylation and proteasomal degradation.
    Title: Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Diamond-Blackfan anemia 11
MedGen: C3554042 OMIM: 614900 GeneReviews: Diamond-Blackfan Anemia
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC co-localizes with ribosomal protein RPL26 in the cytoplasm PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 5'-UTR binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to gamma radiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation involved in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL24
Names
60S ribosomal protein L26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031989.1 RefSeqGene

    Range
    5055..10732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1125

mRNA and Protein(s)

  1. NM_000987.5 → NP_000978.1  large ribosomal subunit protein uL24

    See identical proteins and their annotated locations for NP_000978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK311804, BC071664, BM928617
    Consensus CDS
    CCDS11142.1
    UniProtKB/Swiss-Prot
    B2R4F0, D3DTR8, P61254, Q02877, Q6IPY2
    UniProtKB/TrEMBL
    Q6IBH6
    Related
    ENSP00000498177.1, ENST00000648839.1
    Conserved Domains (1) summary
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

  2. NM_001315530.2 → NP_001302459.1  large ribosomal subunit protein uL24

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC135178, BC071664, BI603704, BM928617
    Consensus CDS
    CCDS11142.1
    UniProtKB/Swiss-Prot
    B2R4F0, D3DTR8, P61254, Q02877, Q6IPY2
    UniProtKB/TrEMBL
    Q6IBH6
    Related
    ENSP00000463784.1, ENST00000584164.6
    Conserved Domains (1) summary
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

  3. NM_001315531.2 → NP_001302460.1  large ribosomal subunit protein uL24

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC135178, BC071664, BI596427, BM928617
    Consensus CDS
    CCDS11142.1
    UniProtKB/Swiss-Prot
    B2R4F0, D3DTR8, P61254, Q02877, Q6IPY2
    UniProtKB/TrEMBL
    Q6IBH6
    Related
    ENSP00000463470.1, ENST00000582556.5
    Conserved Domains (1) summary
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8377516..8383193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    8283737..8289839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316869.1 → XP_054172844.1  large ribosomal subunit protein uL24 isoform X1

    UniProtKB/Swiss-Prot
    B2R4F0, D3DTR8, P61254, Q02877, Q6IPY2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61254.1 GenPept UniProtKB/Swiss-Prot:P61254

Gene LinkOut

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