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FAM229B family with sequence similarity 229 member B [ Homo sapiens (human) ]

Gene ID: 619208, updated on 5-Mar-2024

Summary

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Official Symbol
FAM229Bprovided by HGNC
Official Full Name
family with sequence similarity 229 member Bprovided by HGNC
Primary source
HGNC:HGNC:33858
See related
Ensembl:ENSG00000203778 AllianceGenome:HGNC:33858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf225
Expression
Biased expression in testis (RPKM 37.5), brain (RPKM 9.0) and 10 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (112087591..112102790)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (113271009..113286208)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (112408794..112423993)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cellular communication network factor 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:112408399-112408930 Neighboring gene tubulin epsilon 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:112421446-112422235 Neighboring gene MPRA-validated peak6040 silencer Neighboring gene MPRA-validated peak6041 silencer Neighboring gene uncharacterized LOC107986633 Neighboring gene laminin subunit alpha 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:112462018-112463217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24961 Neighboring gene RNA, U6 small nuclear 1226, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases. Buljan M, et al. Mol Cell, 2020 Aug 6. PMID 32707033, Free PMC Article
  2. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp586F0922

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein FAM229B
Names
UPF0731 protein C6orf225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033564.3 → NP_001028736.1  protein FAM229B

    See identical proteins and their annotated locations for NP_001028736.1

    Status: VALIDATED

    Source sequence(s)
    BC044912, BF110308, Z99289
    Consensus CDS
    CCDS34513.1
    UniProtKB/Swiss-Prot
    B8ZZ33, Q4G0N7
    Related
    ENSP00000357645.2, ENST00000368656.7
    Conserved Domains (1) summary
    pfam14982
    Location:3 → 80
    UPF0731; UPF0731 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    112087591..112102790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011174.3 → XP_016866663.1  protein FAM229B isoform X1

    UniProtKB/Swiss-Prot
    B8ZZ33, Q4G0N7
    Conserved Domains (1) summary
    pfam14982
    Location:3 → 80
    UPF0731; UPF0731 family

  2. XM_017011175.3 → XP_016866664.1  protein FAM229B isoform X1

    UniProtKB/Swiss-Prot
    B8ZZ33, Q4G0N7
    Conserved Domains (1) summary
    pfam14982
    Location:3 → 80
    UPF0731; UPF0731 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    113271009..113286208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356186.1 → XP_054212161.1  protein FAM229B isoform X1

    UniProtKB/Swiss-Prot
    B8ZZ33, Q4G0N7

  2. XM_054356187.1 → XP_054212162.1  protein FAM229B isoform X1

    UniProtKB/Swiss-Prot
    B8ZZ33, Q4G0N7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G0N7.1 GenPept UniProtKB/Swiss-Prot:Q4G0N7

Gene LinkOut

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