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Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 619382, updated on 2-Nov-2024

Summary

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Official Symbol
Acap2provided by RGD
Official Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by RGD
Primary source
RGD:1562939
See related
EnsemblRapid:ENSRNOG00000001730 AllianceGenome:RGD:1562939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Centb2; cnt-b2
Summary
Predicted to enable GTPase activator activity; phosphatidylinositol-3,5-bisphosphate binding activity; and small GTPase binding activity. Involved in cellular response to nerve growth factor stimulus and endocytic recycling. Located in endosome membrane. Orthologous to human ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 208.9), Lung (RPKM 189.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acap2 in Genome Data Viewer
Location:
11q22
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (83043442..83159105)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (69538487..69654156)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (73078966..73193496)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 2, pseudogene 3 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2 Neighboring gene uncharacterized LOC134481096 Neighboring gene xyloside xylosyltransferase 1 Neighboring gene uncharacterized LOC120095678 Neighboring gene uncharacterized LOC120095677

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure-function analyses of the small GTPase Rab35 and its effector protein centaurin-β2/ACAP2 during neurite outgrowth of PC12 cells. Etoh K, et al. J Biol Chem, 2015 Apr 3. PMID 25694427, Free PMC Article
  2. Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination. Miyamoto Y, et al. Mol Biol Cell, 2014 May. PMID 24600047, Free PMC Article
  3. Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth. Kobayashi H, et al. J Cell Sci, 2012 May 1. PMID 22344257
  4. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. Jackson TR, et al. J Cell Biol, 2000 Oct 30. PMID 11062263, Free PMC Article
  5. Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. Kobayashi H, et al. J Cell Sci, 2013 Jun 1. PMID 23572513

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. showed by knockdown-rescue approaches that neither a centaurin-beta2 binding-deficient Rab35(T76S/T81A) mutant nor a Rab35 binding-deficient centaurin-beta2(N610A/N691A) mutant supported neurite outgrowth of PC12 cells
    Title: Structure-function analyses of the small GTPase Rab35 and its effector protein centaurin-β2/ACAP2 during neurite outgrowth of PC12 cells.
  2. Rab35/ACAP2 and cytohesin-2 antagonistically control oligodendrocyte differentiation and myelination through Arf6 regulation.
    Title: Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination.
  3. Rab35 regulates Arf6 activity through centaurin-beta2 (ACAP2) during neurite outgrowth.
    Title: Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament-based process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actin filament-based process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nerve growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Names
centaurin-beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034006.2 → NP_001029178.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

    See identical proteins and their annotated locations for NP_001029178.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q5FVC7
    UniProtKB/TrEMBL
    A0A8L2QG26
    Conserved Domains (6) summary
    PTZ00322
    Location:634 → 718
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    cd13250
    Location:269 → 365
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:630 → 663
    ANK; ANK repeat [structural motif]
    cd08851
    Location:399 → 513
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:602 → 653
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    83043442..83159105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248489.5 → XP_006248551.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QG26
    Conserved Domains (7) summary
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    smart00105
    Location:402 → 517
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:637 → 753
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269 → 365
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 361
    PH; PH domain
    pfam12796
    Location:637 → 731
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:665 → 698
    ANK; ANK repeat [structural motif]

  2. XM_006248487.4 → XP_006248549.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QG26
    Related
    ENSRNOP00000082482.2, ENSRNOT00000094946.2
    Conserved Domains (7) summary
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    smart00105
    Location:409 → 524
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:644 → 760
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269 → 372
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 368
    PH; PH domain
    pfam12796
    Location:644 → 738
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:672 → 705
    ANK; ANK repeat [structural motif]

  3. XM_006248491.5 → XP_006248553.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QG26
    Related
    ENSRNOP00000073162.3, ENSRNOT00000080834.3
    Conserved Domains (7) summary
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    smart00105
    Location:409 → 524
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:609 → 725
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269 → 372
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 368
    PH; PH domain
    pfam12796
    Location:609 → 703
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:637 → 670
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVC7.1 GenPept UniProtKB/Swiss-Prot:Q5FVC7

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