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Med24 mediator complex subunit 24 [ Rattus norvegicus (Norway rat) ]

Gene ID: 619436, updated on 10-Oct-2024

Summary

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Official Symbol
Med24provided by RGD
Official Full Name
mediator complex subunit 24provided by RGD
Primary source
RGD:1564565
See related
EnsemblRapid:ENSRNOG00000008711 AllianceGenome:RGD:1564565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Thrap4
Summary
Enables histone acetyltransferase activity and transcription coactivator activity. Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Located in nucleus. Part of ubiquitin ligase complex. Orthologous to human MED24 (mediator complex subunit 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 124.1), Brain (RPKM 98.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Med24 in Genome Data Viewer
Location:
10q31
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84160866..84198607, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83664609..83702315, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86620166..86658014, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 3 Neighboring gene colony stimulating factor 3 Neighboring gene small nucleolar RNA, C/D box 124 Neighboring gene thyroid hormone receptor alpha Neighboring gene uncharacterized LOC108352130 Neighboring gene nuclear receptor subfamily 1, group D, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. Ito M, et al. EMBO J, 2002 Jul 1. PMID 12093747, Free PMC Article
  2. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. Wang Q, et al. J Biol Chem, 2002 Nov 8. PMID 12218053
  3. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, et al. Proc Natl Acad Sci U S A, 2002 Sep 3. PMID 12189208, Free PMC Article
  4. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149480, Free PMC Article
  5. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Ito M, et al. Mol Cell, 1999 Mar. PMID 10198638

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear thyroid hormone receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of core mediator complex IEA
Inferred from Electronic Annotation
more info
  
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 24
Names
thyroid hormone receptor-associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034079.1 → NP_001029251.1  mediator of RNA polymerase II transcription subunit 24

    See identical proteins and their annotated locations for NP_001029251.1

    Status: VALIDATED

    Source sequence(s)
    BC097461
    UniProtKB/Swiss-Prot
    Q4V8B3
    UniProtKB/TrEMBL
    A0A8I6AA67
    Related
    ENSRNOP00000106783.1, ENSRNOT00000165183.1
    Conserved Domains (1) summary
    pfam11277
    Location:1 → 985
    Med24_N; Mediator complex subunit 24 N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    84160866..84198607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269788.1 → XP_063125858.1  mediator of RNA polymerase II transcription subunit 24 isoform X2

    UniProtKB/Swiss-Prot
    Q4V8B3

  2. XM_017597516.3 → XP_017453005.1  mediator of RNA polymerase II transcription subunit 24 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AA67, A0A8L2Q599, A6HIT9
    Conserved Domains (1) summary
    pfam11277
    Location:1 → 1004
    Med24_N; Mediator complex subunit 24 N-terminal

  3. XM_039086760.1 → XP_038942688.1  mediator of RNA polymerase II transcription subunit 24 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AA67
    Conserved Domains (1) summary
    pfam11277
    Location:1 → 944
    Med24_N; Mediator complex subunit 24 N-terminal

  4. XM_039086759.1 → XP_038942687.1  mediator of RNA polymerase II transcription subunit 24 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AA67
    Conserved Domains (1) summary
    pfam11277
    Location:1 → 963
    Med24_N; Mediator complex subunit 24 N-terminal

  5. XM_006247415.4 → XP_006247477.1  mediator of RNA polymerase II transcription subunit 24 isoform X1

    See identical proteins and their annotated locations for XP_006247477.1

    UniProtKB/TrEMBL
    A0A8I6AA67, A0A8L2Q599, A6HIT9
    Related
    ENSRNOP00000011947.4, ENSRNOT00000011947.6
    Conserved Domains (1) summary
    pfam11277
    Location:1 → 1004
    Med24_N; Mediator complex subunit 24 N-terminal

  6. XM_063269789.1 → XP_063125859.1  mediator of RNA polymerase II transcription subunit 24 isoform X4

  7. XM_063269787.1 → XP_063125857.1  mediator of RNA polymerase II transcription subunit 24 isoform X2

    UniProtKB/Swiss-Prot
    Q4V8B3

  8. XM_006247416.4 → XP_006247478.1  mediator of RNA polymerase II transcription subunit 24 isoform X1

    See identical proteins and their annotated locations for XP_006247478.1

    UniProtKB/TrEMBL
    A0A8I6AA67, A0A8L2Q599, A6HIT9
    Conserved Domains (1) summary
    pfam11277
    Location:1 → 1004
    Med24_N; Mediator complex subunit 24 N-terminal

  9. XM_063269791.1 → XP_063125861.1  mediator of RNA polymerase II transcription subunit 24 isoform X6

  10. XM_039086761.1 → XP_038942689.1  mediator of RNA polymerase II transcription subunit 24 isoform X5

    Conserved Domains (1) summary
    pfam11277
    Location:1 → 589
    Med24_N; Mediator complex subunit 24 N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8B3.1 GenPept UniProtKB/Swiss-Prot:Q4V8B3

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