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Acsf2 acyl-CoA synthetase family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 619561, updated on 2-Nov-2024

Summary

Official Symbol
Acsf2provided by RGD
Official Full Name
acyl-CoA synthetase family member 2provided by RGD
Primary source
RGD:1562656
See related
EnsemblRapid:ENSRNOG00000003330 AllianceGenome:RGD:1562656
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in mitochondrion. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 219.5), Liver (RPKM 109.1) and 8 other tissues See more
Orthologs
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Genomic context

See Acsf2 in Genome Data Viewer
Location:
10q26
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (80001389..80043796, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (79504510..79546714, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (82284719..82326771, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Mycbp associated protein Neighboring gene uncharacterized LOC108352211 Neighboring gene radical S-adenosyl methionine domain containing 1 Neighboring gene chondroadherin Neighboring gene uncharacterized LOC102555790 Neighboring gene leucine rich repeat containing 59 Neighboring gene essential meiotic structure-specific endonuclease 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables medium-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables medium-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables medium-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
medium-chain acyl-CoA ligase ACSF2, mitochondrial
Names
acyl-CoA synthetase family member 2, mitochondrial
NP_001030123.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034951.3NP_001030123.1  medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001030123.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q499N5
    UniProtKB/TrEMBL
    A0A8I6GEJ7
    Related
    ENSRNOP00000004673.4, ENSRNOT00000004673.6
    Conserved Domains (1) summary
    PRK08315
    Location:57615
    PRK08315; AMP-binding domain protein; Validated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    80001389..80043796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_010055237.1 RNA Sequence