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Psme2b protease (prosome, macropain) activator subunit 2B [ Mus musculus (house mouse) ]

Gene ID: 621823, updated on 2-Nov-2024

Summary

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Official Symbol
Psme2bprovided by MGI
Official Full Name
protease (prosome, macropain) activator subunit 2Bprovided by MGI
Primary source
MGI:MGI:1341073
See related
Ensembl:ENSMUSG00000078153 AllianceGenome:MGI:1341073
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PA28b2; PA28b-p; Psme2b-ps; Psme2-like
Summary
This gene may encode proteasome activator complex subunit 2 protein (PMID: 10222192). This gene, located on chromosome 11, lacks a structured promoter and is intronless. It has also been described as a pseudogene (PMID: 9914329), however, it has an intact coding region and transcripts can be placed at this location unambiguously. An interferon-inducible gene located on chromosome 14, near the gene that encodes proteasome activator complex subunit 1 protein, is considered the functional gene. [provided by RefSeq, Jul 2013]
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Genomic context

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See Psme2b in Genome Data Viewer
Location:
11 B1.2; 11 28.93 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48836172..48837237, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (48945345..48946410, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5431 Neighboring gene STARR-positive B cell enhancer ABC_E6975 Neighboring gene predicted gene 12185 Neighboring gene RIKEN cDNA 9930111J21 gene 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:48793591-48793892 Neighboring gene predicted gene, 42074 Neighboring gene STARR-seq mESC enhancer starr_29366 Neighboring gene T cell specific GTPase 1 Neighboring gene poly(rC) binding protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transposable elements and viruses as factors in adaptation and evolution: an expansion and strengthening of the TE-Thrust hypothesis. Oliver KR, et al. Ecol Evol, 2012 Nov. PMID 23170223, Free PMC Article
  2. Characterization of the mouse proteasome regulator PA28b gene. Li Y, et al. Immunogenetics, 1999 Mar. PMID 9914329
  3. Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta. Murata S, et al. EMBO J, 2001 Nov 1. PMID 11689430, Free PMC Article
  4. A second gene encoding the mouse proteasome activator PA28beta subunit is part of a LINE1 element and is driven by a LINE1 promoter. Zaiss DM, et al. J Mol Biol, 1999 Apr 16. PMID 10222192
  5. Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. Jiang H, et al. Immunogenetics, 1997. PMID 9162094

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Psme2b is an expressed retrotransposon. Unlike Psme2, Psme2b is constitutive not cytokine-inducible, as a result of insertion into a transcriptionally active LINE1 element.
    Title: A second gene encoding the mouse proteasome activator PA28beta subunit is part of a LINE1 element and is driven by a LINE1 promoter.
  2. Psme2b is intronless and lacks a structured promoter so appears to be a processed Psme2 pseudogene.
    Title: Characterization of the mouse proteasome regulator PA28b gene.
  3. MEF from mice deficient for PA28a and PA28b do not have detectable mRNA and protein for these proteins even after gamma interferon stimulation, suggesting only one functional copy of PA28a and PA28b.
    Title: Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta.
  4. Induction of PA28 beta expression allows proper PA28 alpha beta complex formation, thereby enhancing proteasome activity in activated dendritic cells.
    Title: Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protease (prosome, macropain) 28 subunit beta B
Names
PA28 beta subunit (PA28b) pseudogene
protease (prosome, macropain) 28 subunit beta B, pseudogene
protease (prosome, macropain) 28 subunit, beta, b
proteasome activator complex like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281472.1 → NP_001268401.1  protease (prosome, macropain) 28 subunit beta B

    See identical proteins and their annotated locations for NP_001268401.1

    Status: REVIEWED

    Source sequence(s)
    BB844325, BE624310, D87910
    Consensus CDS
    CCDS78934.1
    UniProtKB/Swiss-Prot
    O35562, P97372
    UniProtKB/TrEMBL
    A0A1G5SJA5, Q5SVP3
    Related
    ENSMUSP00000100564.2, ENSMUST00000104958.2
    Conserved Domains (2) summary
    pfam02251
    Location:12 → 66
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:94 → 235
    PA28_beta; Proteasome activator pa28 beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    48836172..48837237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_005906.4: Suppressed sequence

    Description
    NG_005906.4: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.

  2. NR_003274.1: Suppressed sequence

    Description
    NR_003274.1: This RefSeq was permanently suppressed because there is insufficient evidence that this locus is transcribed.
Nucleotide Protein Strain
Heading Accession and Version

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