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Rad54b RAD54 homolog B (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 623474, updated on 2-Nov-2024

Summary

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Official Symbol
Rad54bprovided by MGI
Official Full Name
RAD54 homolog B (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:3605986
See related
Ensembl:ENSMUSG00000078773 AllianceGenome:MGI:3605986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130016E03Rik
Summary
Predicted to enable DNA translocase activity. Acts upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to human RAD54B (RAD54 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 3.4), limb E14.5 (RPKM 2.3) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Rad54b in Genome Data Viewer
Location:
4 A1; 4 5.11 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11558930..11615806)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11558920..11615808)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E338 Neighboring gene vir like m6A methyltransferase associated Neighboring gene STARR-seq mESC enhancer starr_09600 Neighboring gene STARR-positive B cell enhancer ABC_E4614 Neighboring gene predicted gene, 53245 Neighboring gene predicted gene, 35693 Neighboring gene fibrinogen silencer binding protein Neighboring gene predicted gene 11832 Neighboring gene eukaryotic translation initiation factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_09604 Neighboring gene predicted gene, 35884

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Susceptibility to DNA damage caused by abrogation of Rad54 homolog B: A putative mechanism for chemically induced cleft palate. Qiao W, et al. Toxicology, 2021 May 30. PMID 33823233
  2. RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway. Mai Y, et al. Can J Physiol Pharmacol, 2024 Feb 1. PMID 37748205
  3. Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination. Bross L, et al. Eur J Immunol, 2003 Feb. PMID 12548566
  4. Genetic probing of homologous recombination and non-homologous end joining during meiotic prophase in irradiated mouse spermatocytes. Ahmed EA, et al. Mutat Res, 2010 Jun 1. PMID 20167225
  5. DNA double-strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation. Derijck A, et al. Hum Mol Genet, 2008 Jul 1. PMID 18353795

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway.
    Title: RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway.
  2. Susceptibility to DNA damage caused by abrogation of Rad54 homolog B: A putative mechanism for chemically induced cleft palate.
    Title: Susceptibility to DNA damage caused by abrogation of Rad54 homolog B: A putative mechanism for chemically induced cleft palate.
  3. Rad54/Rad54B deficiency may impact on the DNA integrity of developing mouse gametes.
    Title: Rad54/Rad54B deficiency is associated to increased chromosome breakage in mouse spermatocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC67261

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA translocase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA translocase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to ionizing radiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA repair and recombination protein RAD54B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039556.4 → NP_001034645.1  DNA repair and recombination protein RAD54B isoform 1

    See identical proteins and their annotated locations for NP_001034645.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732538
    Consensus CDS
    CCDS17970.1
    UniProtKB/Swiss-Prot
    A2AIV0, Q6PFE3
    Related
    ENSMUSP00000066977.7, ENSMUST00000070755.13
    Conserved Domains (4) summary
    cd00046
    Location:299 → 440
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:277 → 576
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:619 → 736
    Helicase_C; Helicase conserved C-terminal domain
    pfam11496
    Location:531 → 807
    HDA2-3; Class II histone deacetylase complex subunits 2 and 3

  2. NM_001256145.2 → NP_001243074.1  DNA repair and recombination protein RAD54B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons but has an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is significantly shorter than isoform 1.
    Source sequence(s)
    AL732538
    Consensus CDS
    CCDS57262.1
    UniProtKB/TrEMBL
    A0A0A0MQB1, A2AIU9
    Related
    ENSMUSP00000092767.6, ENSMUST00000095145.12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11558930..11615806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177285.1: Suppressed sequence

    Description
    NM_177285.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFE3.1 GenPept UniProtKB/Swiss-Prot:Q6PFE3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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