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Lekr1 leucine, glutamate and lysine rich 1 [ Mus musculus (house mouse) ]

Gene ID: 624866, updated on 2-Nov-2024

Summary

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Official Symbol
Lekr1provided by MGI
Official Full Name
leucine, glutamate and lysine rich 1provided by MGI
Primary source
MGI:MGI:3645902
See related
Ensembl:ENSMUSG00000074579 AllianceGenome:MGI:3645902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm6534; EG546798; EG624866
Summary
Orthologous to human LEKR1 (leucine, glutamate and lysine rich 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 1.2), CNS E18 (RPKM 0.7) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Lekr1 in Genome Data Viewer
Location:
3 E1; 3 30.24 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (65566960..65743948)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (65659539..65836527)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_07866 Neighboring gene STARR-seq mESC enhancer starr_07867 Neighboring gene STARR-positive B cell enhancer ABC_E11189 Neighboring gene predicted gene, 54197 Neighboring gene microRNA 8120 Neighboring gene STARR-seq mESC enhancer starr_07869 Neighboring gene STARR-seq mESC enhancer starr_07870 Neighboring gene predicted gene, 25755 Neighboring gene predicted gene, 54198 Neighboring gene STARR-positive B cell enhancer ABC_E9008 Neighboring gene predicted gene, 35039

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of cell-type-specific gene expression during mouse spermatogenesis. Almstrup K, et al. Biol Reprod, 2004 Jun. PMID 14960480
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein LEKR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037923.4 → NP_001033012.2  protein LEKR1 isoform 2

    See identical proteins and their annotated locations for NP_001033012.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC114650, AK137452, BB373830, CJ137734
    Consensus CDS
    CCDS17389.1
    UniProtKB/TrEMBL
    B2RVN1, Q3UVB4
    Related
    ENSMUSP00000096674.3, ENSMUST00000099075.4
    Conserved Domains (1) summary
    pfam10498
    Location:33 → 85
    IFT57; Intra-flagellar transport protein 57

  2. NM_001166659.1 → NP_001160131.1  protein LEKR1 isoform 1

    See identical proteins and their annotated locations for NP_001160131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the full-length isoform (1). The exon combination of this variant is predicted based on orthologous transcript alignments.
    Source sequence(s)
    AC110245, AC114650
    UniProtKB/TrEMBL
    A0A571BF98
    Related
    ENSMUSP00000158835.2, ENSMUST00000177434.3
    Conserved Domains (1) summary
    COG1196
    Location:260 → 591
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    65566960..65743948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501847.3 → XP_006501910.1  protein LEKR1 isoform X3

    See identical proteins and their annotated locations for XP_006501910.1

    UniProtKB/TrEMBL
    A0A571BF98
    Conserved Domains (1) summary
    COG1196
    Location:260 → 591
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_006501844.2 → XP_006501907.1  protein LEKR1 isoform X1

    See identical proteins and their annotated locations for XP_006501907.1

    Conserved Domains (1) summary
    COG1196
    Location:71 → 402
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_011240186.3 → XP_011238488.1  protein LEKR1 isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:106 → 395
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version

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