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RSU1 Ras suppressor protein 1 [ Homo sapiens (human) ]

Gene ID: 6251, updated on 5-Mar-2024

Summary

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Official Symbol
RSU1provided by HGNC
Official Full Name
Ras suppressor protein 1provided by HGNC
Primary source
HGNC:HGNC:10464
See related
Ensembl:ENSG00000148484 MIM:179555; AllianceGenome:HGNC:10464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSP-1
Summary
This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 25.2), endometrium (RPKM 23.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10p13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (16590611..16817424, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (16609081..16835881, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (16632610..16859423, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 18, pseudogene Neighboring gene phosphotriesterase related Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:16561428-16561928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:16561929-16562429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3099 Neighboring gene complement C1q like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3100 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:16639108-16640307 Neighboring gene uncharacterized LOC124902385 Neighboring gene uncharacterized LOC124902384 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:16801281-16801433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:16829435-16829935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3106 Neighboring gene uncharacterized LOC105376435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3105 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:16864864-16865015 Neighboring gene MPRA-validated peak881 silencer Neighboring gene MPRA-validated peak882 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:16933270-16934469 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:16942960-16943677 Neighboring gene cubilin Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:16970960-16971553 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:17010389-17010952 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:17026880-17027039 Neighboring gene GATA motif-containing MPRA enhancer 283 Neighboring gene Sharpr-MPRA regulatory region 1431 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:17104252-17105451 Neighboring gene MPRA-validated peak883 silencer Neighboring gene MPRA-validated peak884 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:17157167-17158366

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in invasive breast cancer cells. Christou C, et al. Cell Signal, 2023 Jan. PMID 36375714
  2. Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma. Nikou S, et al. Clin Exp Med, 2023 Jul. PMID 35729367
  3. Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance. Geramoutsou C, et al. Pathol Res Pract, 2022 Jul. PMID 35642986
  4. Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform. Gkretsi V, et al. Sci Rep, 2019 Jul 11. PMID 31296919, Free PMC Article
  5. Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation. Louca M, et al. Sci Rep, 2019 May 23. PMID 31123330, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircRSU1 alleviates LPS-induced human pulmonary microvascular endothelial cell injury by targeting miR-1224-5p/ITGA5 axis.
    Title: CircRSU1 alleviates LPS-induced human pulmonary microvascular endothelial cell injury by targeting miR-1224-5p/ITGA5 axis.
  2. Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma.
    Title: Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma.
  3. Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in invasive breast cancer cells.
    Title: Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in invasive breast cancer cells.
  4. Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance.
    Title: Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance.
  5. Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
    Title: Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
  6. Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
    Title: Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
  7. RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling.
    Title: RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling.
  8. Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
    Title: Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
  9. MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
    Title: MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
  10. Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform.
    Title: Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
CUBN is a gene locus for albuminuria.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31034

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ras suppressor protein 1
Names
rsu-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012425.4 → NP_036557.1  ras suppressor protein 1 isoform 1

    See identical proteins and their annotated locations for NP_036557.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC073367, AK055596, BC005993, BG400752, BX647733
    Consensus CDS
    CCDS7112.1
    UniProtKB/Swiss-Prot
    A8KA46, D3DRU3, Q15404, Q6FI17
    UniProtKB/TrEMBL
    Q32Q10
    Related
    ENSP00000339521.5, ENST00000345264.10
    Conserved Domains (2) summary
    PLN00113
    Location:34 → 200
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:19 → 41
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_152724.3 → NP_689937.2  ras suppressor protein 1 isoform 2

    See identical proteins and their annotated locations for NP_689937.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1. This transcript is supported by multiple ESTs, but the predicted ORF has not yet been experimentally confirmed.
    Source sequence(s)
    AC073367, AK055596, BG400752, BX647733
    Consensus CDS
    CCDS31157.1
    UniProtKB/TrEMBL
    Q32Q10
    Related
    ENSP00000473588.1, ENST00000602389.1
    Conserved Domains (3) summary
    cd00116
    Location:27 → 140
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:12 → 34
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:34 → 93
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    16590611..16817424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425617.1 → XP_047281573.1  ras suppressor protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    16609081..16835881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366524.1 → XP_054222499.1  ras suppressor protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15404.3 GenPept UniProtKB/Swiss-Prot:Q15404

Gene LinkOut

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