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Dnah7a dynein, axonemal, heavy chain 7A [ Mus musculus (house mouse) ]

Gene ID: 627872, updated on 2-Nov-2024

Summary

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Official Symbol
Dnah7aprovided by MGI
Official Full Name
dynein, axonemal, heavy chain 7Aprovided by MGI
Primary source
MGI:MGI:2685838
See related
Ensembl:ENSMUSG00000096141 AllianceGenome:MGI:2685838
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm992; Dnahc7; Dnahc7a
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within cilium movement and inner dynein arm assembly. Predicted to be located in cilium and cytosol. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in spermatozoon and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DNAH7 (dynein axonemal heavy chain 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 4.9) and CNS E18 (RPKM 0.2) See more
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Genomic context

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See Dnah7a in Genome Data Viewer
Location:
1 C1.1; 1 26.99 cM
Exon count:
66
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (53436154..53746456, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (53396995..53707301, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2543 Neighboring gene asparagine synthetase domain containing 1 Neighboring gene Asnsd1 upstream reading frame Neighboring gene predicted gene, 53553 Neighboring gene solute carrier family 39 (zinc transporter), member 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00916 Neighboring gene STARR-seq mESC enhancer starr_00917 Neighboring gene STARR-seq mESC enhancer starr_00918 Neighboring gene STARR-seq mESC enhancer starr_00919 Neighboring gene STARR-seq mESC enhancer starr_00920 Neighboring gene STARR-positive B cell enhancer ABC_E7724 Neighboring gene STARR-seq mESC enhancer starr_00921 Neighboring gene STARR-seq mESC enhancer starr_00924 Neighboring gene predicted gene, 32311 Neighboring gene STARR-positive B cell enhancer ABC_E627 Neighboring gene STARR-positive B cell enhancer ABC_E1544 Neighboring gene STARR-positive B cell enhancer ABC_E3276 Neighboring gene STARR-seq mESC enhancer starr_00925 Neighboring gene serine/threonine kinase 17b (apoptosis-inducing) Neighboring gene STARR-positive B cell enhancer ABC_E7726 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene microRNA 7681

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. Dong F, et al. J Cell Biol, 2014 Jan 20. PMID 24421334, Free PMC Article
  2. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Neesen J, et al. Gene, 1997 Oct 24. PMID 9373155
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inner dynein arm ISM
Inferred from Sequence Model
more info
 PubMed 
part_of inner dynein arm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein, axonemal, heavy chain 7A
Names
dynein, axonemal, heavy chain 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252070.1 → NP_001238999.1  dynein, axonemal, heavy chain 7A

    Status: PROVISIONAL

    Source sequence(s)
    AC100561, AC122925, AC138328, AC153650, AK038423
    Consensus CDS
    CCDS56629.1
    UniProtKB/TrEMBL
    E9Q0T8, L7N1Y0
    Related
    ENSMUSP00000092571.6, ENSMUST00000094964.7
    Conserved Domains (6) summary
    pfam03028
    Location:3318 → 4012
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:759 → 1163
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:2587 → 2933
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:2963 → 3178
    AAA_9; ATP-binding dynein motor region D5
    cl02488
    Location:576 → 764
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21455
    Location:1290 → 1520
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    53436154..53746456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496179.4 → XP_006496242.1  dynein, axonemal, heavy chain 7A isoform X3

    UniProtKB/TrEMBL
    L7N1Y0
    Conserved Domains (6) summary
    COG5245
    Location:894 → 3688
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08393
    Location:779 → 1184
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1312 → 1638
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2333 → 2593
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:2985 → 3201
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:3742 → 4042
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_017321900.3 → XP_017177389.1  dynein, axonemal, heavy chain 7A isoform X1

    Conserved Domains (8) summary
    pfam12777
    Location:2609 → 2949
    MT; Microtubule-binding stalk of dynein motor
    pfam08393
    Location:779 → 1184
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1312 → 1638
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12775
    Location:1960 → 2140
    AAA_7; P-loop containing dynein motor region D3
    pfam12780
    Location:2333 → 2593
    AAA_8; P-loop containing dynein motor region D4
    pfam17852
    Location:1804 → 1951
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    pfam17857
    Location:2174 → 2269
    AAA_lid_1; AAA+ lid domain
    cl38936
    Location:1626 → 1769
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_036152679.1 → XP_036008572.1  dynein, axonemal, heavy chain 7A isoform X2

    Conserved Domains (6) summary
    pfam17857
    Location:2174 → 2233
    AAA_lid_1; AAA+ lid domain
    pfam08393
    Location:779 → 1184
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1312 → 1638
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12775
    Location:1960 → 2140
    AAA_7; P-loop containing dynein motor region D3
    pfam17852
    Location:1804 → 1951
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    cl38936
    Location:1626 → 1769
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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