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Cd101 CD101 antigen [ Mus musculus (house mouse) ]

Gene ID: 630146, updated on 2-Nov-2024

Summary

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Official Symbol
Cd101provided by MGI
Official Full Name
CD101 antigenprovided by MGI
Primary source
MGI:MGI:2685862
See related
Ensembl:ENSMUSG00000086564 AllianceGenome:MGI:2685862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm734; Igsf2; Gm1016; EWI-101
Summary
Acts upstream of or within positive regulation of myeloid leukocyte differentiation. Predicted to be active in membrane. Orthologous to human CD101 (CD101 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 1.1), lung adult (RPKM 0.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Cd101 in Genome Data Viewer
Location:
3 F2.2; 3 43.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100899505..100936869, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100992189..101029553, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E232 Neighboring gene tripartite motif-containing 45 Neighboring gene STARR-positive B cell enhancer ABC_E2678 Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene STARR-seq mESC enhancer starr_08505 Neighboring gene prostaglandin F2 receptor negative regulator Neighboring gene STARR-seq mESC enhancer starr_08514 Neighboring gene STARR-seq mESC enhancer starr_08516 Neighboring gene STARR-seq mESC enhancer starr_08517 Neighboring gene STARR-seq mESC enhancer starr_08518 Neighboring gene nuclear import 7 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic mice. Robles DT, et al. Diabetes, 2003 Mar. PMID 12606534
  2. Induction of Siglec-F(hi)CD101(hi) eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection. Chetty A, et al. Front Immunol, 2023. PMID 37251384, Free PMC Article
  3. Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. Rainbow DB, et al. J Immunol, 2011 Jul 1. PMID 21613616, Free PMC Article
  4. CD101 inhibits the expansion of colitogenic T cells. Schey R, et al. Mucosal Immunol, 2016 Sep. PMID 26813346, Free PMC Article
  5. Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity. Mohammed JP, et al. J Immunol, 2011 Jul 1. PMID 21613619, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Induction of Siglec-F[hi]CD101[hi] eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.
    Title: Induction of Siglec-F(hi)CD101(hi) eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.
  2. ur results connect the Cd101 haplotype-dependent protection from T1D to an anti-diabetogenic function of CD101-expressing Tregs and Gr1-positive myeloid cells and confirm the identity of Cd101 as Idd10.
    Title: Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.
  3. CD101 inhibits the expansion of colitogenic T cells.
    Title: CD101 inhibits the expansion of colitogenic T cells.
  4. A gene region (Idd10) previously shown to influence susceptibility to type 1 diabetes in the NOD mouse also influences an autoimmune disease involving a different tissue, the liver, which follows an infection with Novosphingobium aromaticivorans.
    Title: Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity.
  5. Further support is provided for the hypothesis that Cd101 is insulin-dependent diabetes susceptibility region 10 (Idd10); haplotype and expression analyses of novel Idd10 congenic strains are coupled to the development of a CD101 knockout mouse.
    Title: Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.
  6. of the eight genes found in the Idd10 region, the CD101 gene was selected as a candidate for Idd10 based on its function in humans and its polymorphism in the NOD strain of mice
    Title: Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.
  7. Cd101, but not Fcgr1, is responsible for the Idd10 effect
    Title: Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of myeloid leukocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily member 2
Names
EWI immunoglobulin subfamily member EWI-101
glu-Trp-Ile EWI motif-containing protein 101
immunoglobulin superfamily, member 2
leukocyte surface protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167906.2 → NP_001161378.1  immunoglobulin superfamily member 2 precursor

    See identical proteins and their annotated locations for NP_001161378.1

    Status: VALIDATED

    Source sequence(s)
    AL669872
    Consensus CDS
    CCDS51020.1
    UniProtKB/Swiss-Prot
    A8E0Y8, A8E0Y9
    UniProtKB/TrEMBL
    A0A0B4J1L8
    Related
    ENSMUSP00000116643.3, ENSMUST00000147399.9
    Conserved Domains (5) summary
    cd00096
    Location:300 → 391
    Ig; Immunoglobulin domain
    smart00410
    Location:29 → 142
    IG_like; Immunoglobulin like
    pfam00047
    Location:421 → 515
    ig; Immunoglobulin domain
    pfam07686
    Location:26 → 143
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:831 → 927
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    100899505..100936869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099332.2: Suppressed sequence

    Description
    NM_001099332.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8E0Y8.1 GenPept UniProtKB/Swiss-Prot:A8E0Y8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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