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Tagln3 transgelin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 63837, updated on 2-Nov-2024

Summary

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Symbol
Tagln3provided by RGD
Full Name
transgelin 3provided by RGD
Primary source
RGD:69301
See related
EnsemblRapid:ENSRNOG00000064186 AllianceGenome:RGD:69301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Np22; Np25
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in actin cytoskeleton and synapse. Orthologous to human TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 974.7) See more
Orthologs
human mouse all
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Genomic context

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See Tagln3 in Genome Data Viewer
Location:
11q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (68562482..68576058)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55099887..55113457)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60072983..60086552)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology-like domain, family B, member 2 Neighboring gene small nucleolar RNA U13 Neighboring gene abhydrolase domain containing 10, depalmitoylase Neighboring gene transmembrane serine protease 7 Neighboring gene similar to human chromosome 3 open reading frame 52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The novel cytoskeleton-associated protein Neuronal protein 22: elevated expression in the developing rat brain. Depaz IM, et al. Brain Res, 2006 Apr 7. PMID 16542643
  2. Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain. Fan L, et al. J Neurochem, 2001 Mar. PMID 11238712
  3. The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations. Ren WZ, et al. Brain Res Mol Brain Res, 1994 Mar. PMID 8015377
  4. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Feng J, et al. Biol Reprod, 2008 Sep. PMID 18480465, Free PMC Article
  5. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transgelin-3
Names
neuronal protein 22
neuronal protein Np25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035236.1 → NP_001030313.1  transgelin-3

    See identical proteins and their annotated locations for NP_001030313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF459788, M84725
    UniProtKB/Swiss-Prot
    P37805, Q09025, Q8VHH3
    UniProtKB/TrEMBL
    A0A8L2UHL4, A6IQX9
    Related
    ENSRNOP00000072985.1, ENSRNOT00000090230.3
    Conserved Domains (2) summary
    pfam00402
    Location:174 → 198
    Calponin; Calponin family repeat
    cd21281
    Location:23 → 141
    CH_TAGLN3; calponin homology (CH) domain found in transgelin-3

  2. NM_031676.2 → NP_113864.2  transgelin-3

    See identical proteins and their annotated locations for NP_113864.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF459788, CB795348, M84725
    UniProtKB/Swiss-Prot
    P37805, Q09025, Q8VHH3
    UniProtKB/TrEMBL
    A0A8L2UHL4, A6IQX9
    Conserved Domains (2) summary
    pfam00402
    Location:174 → 198
    Calponin; Calponin family repeat
    cd21281
    Location:23 → 141
    CH_TAGLN3; calponin homology (CH) domain found in transgelin-3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    68562482..68576058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088610.2 → XP_038944538.1  transgelin-3 isoform X1

    Conserved Domains (2) summary
    pfam00402
    Location:90 → 114
    Calponin; Calponin family repeat
    cl00030
    Location:1 → 70
    CH_SF; calponin homology (CH) domain superfamily

  2. XM_039088609.2 → XP_038944537.1  transgelin-3 isoform X1

    Conserved Domains (2) summary
    pfam00402
    Location:90 → 114
    Calponin; Calponin family repeat
    cl00030
    Location:1 → 70
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37805.2 GenPept UniProtKB/Swiss-Prot:P37805

Gene LinkOut

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