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Pter phosphotriesterase related [ Rattus norvegicus (Norway rat) ]

Gene ID: 63852, updated on 10-Oct-2024

Summary

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Official Symbol
Pterprovided by RGD
Official Full Name
phosphotriesterase relatedprovided by RGD
Primary source
RGD:61313
See related
EnsemblRapid:ENSRNOG00000017328 AllianceGenome:RGD:61313
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rpr1; Rpr-1
Summary
Predicted to enable hydrolase activity, acting on ester bonds and zinc ion binding activity. Predicted to be involved in epithelial cell differentiation. Orthologous to human PTER (phosphotriesterase related). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 462.1) and Spleen (RPKM 29.4) See more
Orthologs
human mouse all
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Genomic context

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See Pter in Genome Data Viewer
Location:
17q12.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (80967463..81028707)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (76058388..76119633)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (80250444..80311987)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555562 Neighboring gene uncharacterized LOC108348618 Neighboring gene uncharacterized LOC134482609 Neighboring gene complement C1q like 3 Neighboring gene Ras suppressor protein 1 Neighboring gene uncharacterized LOC134482610

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression pattern of rpr-1, a resiniferatoxin-binding, phosphotriesterase-related protein, expressed in rat kidney tubules. Davies JA, et al. FEBS Lett, 1997 Jun 30. PMID 9237666
  2. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Buhrke T, et al. Dev Growth Differ, 2011 Apr. PMID 21492153
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphotriesterase-related protein
Names
parathion hydrolase-related protein
resiniferatoxin-binding, phosphotriesterase-related protein
resiniferotoxin-binding phosphotriesterase-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022224.2 → NP_071560.2  phosphotriesterase-related protein

    See identical proteins and their annotated locations for NP_071560.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078833
    UniProtKB/Swiss-Prot
    Q63530, Q6AYY7
    UniProtKB/TrEMBL
    A0A8I5ZP46, A6JM34
    Related
    ENSRNOP00000104743.1, ENSRNOT00000148097.1
    Conserved Domains (1) summary
    cl00281
    Location:15 → 347
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    80967463..81028707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254291.5 → XP_006254353.1  phosphotriesterase-related protein isoform X3

    See identical proteins and their annotated locations for XP_006254353.1

    UniProtKB/Swiss-Prot
    Q63530, Q6AYY7
    UniProtKB/TrEMBL
    A0A8I5ZP46, A6JM34
    Related
    ENSRNOP00000023446.2, ENSRNOT00000023446.6
    Conserved Domains (1) summary
    cl00281
    Location:15 → 347
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  2. XM_039096043.2 → XP_038951971.1  phosphotriesterase-related protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZP46
    Conserved Domains (1) summary
    cl00281
    Location:59 → 391
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  3. XM_006254290.5 → XP_006254352.3  phosphotriesterase-related protein isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63530.2 GenPept UniProtKB/Swiss-Prot:Q63530

Gene LinkOut

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