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Rapgef1 Rap guanine nucleotide exchange factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 63881, updated on 2-Nov-2024

Summary

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Official Symbol
Rapgef1provided by RGD
Official Full Name
Rap guanine nucleotide exchange factor 1provided by RGD
Primary source
RGD:619793
See related
EnsemblRapid:ENSRNOG00000014316 AllianceGenome:RGD:619793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
C3g; Grf2; C3G-1; C3G-2
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of Fc receptor mediated stimulatory signaling pathway; positive regulation of cellular component organization; and regulation of MAPK cascade. Located in perinuclear region of cytoplasm and phagocytic vesicle membrane. Part of protein-containing complex. Biomarker of anti-basement membrane glomerulonephritis and mesangial proliferative glomerulonephritis. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 102.4), Heart (RPKM 94.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rapgef1 in Genome Data Viewer
Location:
3p12
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33296211..33414119)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (12898349..13016234)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8189594..8307077)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene netrin G2 Neighboring gene mediator complex subunit 27 Neighboring gene uncharacterized LOC134486065 Neighboring gene uncharacterized LOC134486064 Neighboring gene golgin A2 like 1 Neighboring gene proline rich transmembrane protein 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel splice variant of C3G which shows tissue-specific expression. Shivakrupa, et al. DNA Cell Biol, 1999 Sep. PMID 10492401
  2. Elevated expression of C3G protein in the peri-infarct myocardium of rats. Wang L, et al. Med Sci Monit Basic Res, 2013 Jan 1. PMID 23291598, Free PMC Article
  3. The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1. Liu E, et al. Cancer Res, 2000 May 1. PMID 10811109
  4. C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis. Rufanova VA, et al. Kidney Int, 2009 Jan. PMID 18784646, Free PMC Article
  5. Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax. Yang D, et al. Clin Exp Pharmacol Physiol, 2019 Mar. PMID 30152875

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. silencing of C3G can increase cell survival inhibition and apoptosis in cardiomyocytes via regulation of p-ERK1/2 and Bax
    Title: Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax.
  2. C3G acts as a pro-survival molecule in H9C2 cardiomyocytes by activation of phosphorylated-ERK1/2.
    Title: C3G overexpression promotes the survival of rat-derived H9C2 cardiomyocytes by p-ERK1/2.
  3. C3G protein expression exhibits in the myocardium of rats.
    Title: Elevated expression of C3G protein in the peri-infarct myocardium of rats.
  4. In mesangioproliferative glomerulonephritis (MPG), C3G is upregulated in glomerular mesangial cells (GMC). Increased C3G may contribute to the resolution stage of MPG by reducing GMC sensitivity to ET-1, modulating cellular motility, and actin dynamics.
    Title: Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells.
  5. C3G was overexpressed in accelerated anti-GBM antibody-induced glomerulonephritis and suggest that this modulates glomerular epithelial cell morphology and behavior
    Title: C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis.
  6. Rap1 and its exchange factor C3G in mediating Fc gammaR-dependent phagocytosis.
    Title: Rap1 activation is required for Fc gamma receptor-dependent phagocytosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in nerve growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell junction assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rap guanine nucleotide exchange factor 1
Names
Rap guanine nucleotide exchange factor (GEF) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427397.1 → NP_001414326.1  rap guanine nucleotide exchange factor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    Related
    ENSRNOP00000088594.1, ENSRNOT00000108449.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    33296211..33414119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106160.2 → XP_038962088.1  rap guanine nucleotide exchange factor 1 isoform X5

    UniProtKB/TrEMBL
    F1M8L9
    Conserved Domains (3) summary
    smart00147
    Location:1015 → 1244
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:867 → 1008
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:217 → 338
    PHA03247; large tegument protein UL36; Provisional

  2. XM_063284486.1 → XP_063140556.1  rap guanine nucleotide exchange factor 1 isoform X8

    Related
    ENSRNOP00000102988.1, ENSRNOT00000161849.1

  3. XM_063284494.1 → XP_063140564.1  rap guanine nucleotide exchange factor 1 isoform X27

    Related
    ENSRNOP00000081072.1, ENSRNOT00000093970.2

  4. XM_039106164.2 → XP_038962092.1  rap guanine nucleotide exchange factor 1 isoform X12

    UniProtKB/TrEMBL
    F1M8L9
    Conserved Domains (3) summary
    smart00147
    Location:977 → 1206
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:829 → 970
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:179 → 300
    PHA03247; large tegument protein UL36; Provisional

  5. XM_063284487.1 → XP_063140557.1  rap guanine nucleotide exchange factor 1 isoform X15

  6. XM_063284489.1 → XP_063140559.1  rap guanine nucleotide exchange factor 1 isoform X18

    Related
    ENSRNOP00000082703.2, ENSRNOT00000095571.2

  7. XM_063284488.1 → XP_063140558.1  rap guanine nucleotide exchange factor 1 isoform X16

  8. XM_063284495.1 → XP_063140565.1  rap guanine nucleotide exchange factor 1 isoform X29

  9. XM_039106157.2 → XP_038962085.1  rap guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    F1M8L9
    Conserved Domains (3) summary
    smart00147
    Location:1028 → 1257
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:880 → 1021
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:230 → 351
    PHA03247; large tegument protein UL36; Provisional

  10. XM_039106162.2 → XP_038962090.1  rap guanine nucleotide exchange factor 1 isoform X9

    UniProtKB/TrEMBL
    F1M8L9
    Conserved Domains (3) summary
    smart00147
    Location:996 → 1225
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:848 → 989
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:230 → 802
    PHA03247; large tegument protein UL36; Provisional

  11. XM_039106167.2 → XP_038962095.1  rap guanine nucleotide exchange factor 1 isoform X19

    UniProtKB/TrEMBL
    A0A8I5ZQV4
    Conserved Domains (3) summary
    smart00147
    Location:910 → 1139
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:762 → 903
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:230 → 351
    PHA03247; large tegument protein UL36; Provisional

  12. XM_039106158.2 → XP_038962086.1  rap guanine nucleotide exchange factor 1 isoform X2

    UniProtKB/TrEMBL
    F1M8L9
    Conserved Domains (3) summary
    smart00147
    Location:1027 → 1256
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:879 → 1020
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:230 → 351
    PHA03247; large tegument protein UL36; Provisional

  13. XM_063284490.1 → XP_063140560.1  rap guanine nucleotide exchange factor 1 isoform X20

  14. XM_039106165.2 → XP_038962093.1  rap guanine nucleotide exchange factor 1 isoform X13

    UniProtKB/TrEMBL
    F1M8L9
    Conserved Domains (3) summary
    smart00147
    Location:976 → 1205
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:828 → 969
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:230 → 351
    PHA03247; large tegument protein UL36; Provisional

  15. XM_063284491.1 → XP_063140561.1  rap guanine nucleotide exchange factor 1 isoform X22

  16. XM_039106168.2 → XP_038962096.1  rap guanine nucleotide exchange factor 1 isoform X23

    UniProtKB/TrEMBL
    A0A8I5ZRV1
    Conserved Domains (3) summary
    smart00147
    Location:858 → 1087
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:710 → 851
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:230 → 351
    PHA03247; large tegument protein UL36; Provisional

  17. XM_039106159.2 → XP_038962087.1  rap guanine nucleotide exchange factor 1 isoform X4

    UniProtKB/TrEMBL
    F1M8L9
    Conserved Domains (3) summary
    smart00147
    Location:1019 → 1248
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:871 → 1012
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:230 → 342
    PHA03247; large tegument protein UL36; Provisional

  18. XM_063284492.1 → XP_063140562.1  rap guanine nucleotide exchange factor 1 isoform X24

  19. XM_017592102.3 → XP_017447591.1  rap guanine nucleotide exchange factor 1 isoform X3

    UniProtKB/TrEMBL
    F1M8L9

  20. XM_008761683.4 → XP_008759905.2  rap guanine nucleotide exchange factor 1 isoform X6

    UniProtKB/TrEMBL
    F1M8L9

  21. XM_008761684.4 → XP_008759906.2  rap guanine nucleotide exchange factor 1 isoform X11

    UniProtKB/TrEMBL
    F1M8L9

  22. XM_039106161.2 → XP_038962089.1  rap guanine nucleotide exchange factor 1 isoform X7

    UniProtKB/TrEMBL
    F1M8L9
    Conserved Domains (3) summary
    smart00147
    Location:1012 → 1241
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:864 → 1005
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PRK14950
    Location:219 → 321
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional

  23. XM_017592108.3 → XP_017447597.1  rap guanine nucleotide exchange factor 1 isoform X21

    UniProtKB/TrEMBL
    A0A8I5ZQV4

  24. XM_006233902.5 → XP_006233964.1  rap guanine nucleotide exchange factor 1 isoform X25

    See identical proteins and their annotated locations for XP_006233964.1

    UniProtKB/TrEMBL
    A0A8I5ZRV1
    Related
    ENSRNOP00000080887.2, ENSRNOT00000099738.2
    Conserved Domains (2) summary
    smart00147
    Location:843 → 1072
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:695 → 836
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

  25. XM_039106163.2 → XP_038962091.1  rap guanine nucleotide exchange factor 1 isoform X10

    UniProtKB/TrEMBL
    F1M8L9
    Conserved Domains (3) summary
    smart00147
    Location:990 → 1219
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:842 → 983
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:192 → 313
    PHA03247; large tegument protein UL36; Provisional

  26. XM_008761685.4 → XP_008759907.2  rap guanine nucleotide exchange factor 1 isoform X14

    UniProtKB/TrEMBL
    F1M8L9

  27. XM_008761686.4 → XP_008759908.2  rap guanine nucleotide exchange factor 1 isoform X17

    UniProtKB/TrEMBL
    F1M8L9

  28. XM_063284493.1 → XP_063140563.1  rap guanine nucleotide exchange factor 1 isoform X26

  29. XM_039106169.2 → XP_038962097.1  rap guanine nucleotide exchange factor 1 isoform X28

    UniProtKB/TrEMBL
    A0A8I5ZUL6
    Conserved Domains (4) summary
    PLN03209
    Location:191 → 429
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    smart00147
    Location:805 → 1034
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:657 → 798
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03247
    Location:192 → 298
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
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