Nmu neuromedin U [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Nmuprovided by RGD
Official Full Name: neuromedin Uprovided by RGD
Primary source: RGD:68388
See related: EnsemblRapid:ENSRNOG00000002164 AllianceGenome:RGD:68388
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables type 1 neuromedin U receptor binding activity and type 2 neuromedin U receptor binding activity. Involved in several processes, including negative regulation of digestive system process; positive regulation of cell communication; and positive regulation of sensory perception of pain. Acts upstream of or within neuropeptide signaling pathway. Located in terminal bouton. Used to study obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMU (neuromedin U). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 3.1), Testes (RPKM 1.8) and 8 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (32198789..32226397)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (31844564..31872196)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (34353683..34381968)

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of neuropeptide neuromedin U in the nucleus accumbens shell in cocaine self-administration in male rats.
Title: Role of neuropeptide neuromedin U in the nucleus accumbens shell in cocaine self-administration in male rats.
Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
Title: Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
This is the first report to demonstrate that Nmu expression in the pars tuberalis is regulated by adenosine, which acts as an intravital central metabolic signal, in addition to melatonin, which acts as an external photoperiodic environmental signal.
Title: Adenosine stimulates neuromedin U mRNA expression in the rat pars tuberalis.
PEGylated rat NMU-8 showed potent and robust anorectic activity and anti-obesity effect in diet-induced obesity mice.
Title: PEGylated neuromedin U-8 shows long-lasting anorectic activity and anti-obesity effect in mice by peripheral administration.
These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU.
Title: Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.
The results demonstrated that, when injected into the lateral brain ventricle NmU increased the body temperature, mediated by CRHR1 and CRHR2, dopamine and muscarinic cholinergic receptors.
Title: Mediators involved in the hyperthermic action of neuromedin U in rats.
study of NMU signalling reveals the potential for a new player in the control of seasonal biology
Title: Neuromedin U partly mimics thyroid-stimulating hormone and triggers Wnt/β-catenin signalling in the photoperiodic response of F344 rats.
Melatonin negatively regulates neuromedin U mRNA expression in the rat pars tuberalis.
Title: Negative regulation of neuromedin U mRNA expression in the rat pars tuberalis by melatonin.
Functional evidence that NMU can have an important effect on the cardiovascular and reflex responses that are integrated in the rostral ventrolateral medulla.
Title: Neuromedin U causes biphasic cardiovascular effects and impairs baroreflex function in rostral ventrolateral medulla of spontaneously hypertensive rat.
NMU and NMU receptor 2 compose a novel autocrine system in theca/interstitial cells in which the intensity of signaling is tightly controlled by gonadotropins.
Title: Ovarian regulation of neuromedin U and its local actions in the ovary, mediated through neuromedin U receptor 2.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuromedin U receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuromedin U receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables neuromedin U receptor binding	IEA Inferred from Electronic Annotation more info
enables type 1 neuromedin U receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type 1 neuromedin U receptor binding	IEA Inferred from Electronic Annotation more info
enables type 1 neuromedin U receptor binding	ISO Inferred from Sequence Orthology more info
enables type 2 neuromedin U receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type 2 neuromedin U receptor binding	IEA Inferred from Electronic Annotation more info
enables type 2 neuromedin U receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in eating behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in energy homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of eating behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gastric acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gastric emptying	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in photoperiodism	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heart rate	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heat generation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prolactin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stomach fundus smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of grooming behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuromedin-U

Names: neuromedin U precursor-related peptide/neuromedin U preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.