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ZNF667 zinc finger protein 667 [ Homo sapiens (human) ]

Gene ID: 63934, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF667provided by HGNC
Official Full Name
zinc finger protein 667provided by HGNC
Primary source
HGNC:HGNC:28854
See related
Ensembl:ENSG00000198046 MIM:611024; AllianceGenome:HGNC:28854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIPU1
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in brain (RPKM 3.0), thyroid (RPKM 2.8) and 22 other tissues See more
Orthologs
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Genomic context

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See ZNF667 in Genome Data Viewer
Location:
19q13.43
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56439329..56478093, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59533762..59572529, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56950698..56988714, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF582 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11069 Neighboring gene zinc finger protein 583 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:56968363-56969562 Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105372471 Neighboring gene uncharacterized LOC124904776

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF667 Serves as a Putative Oncogene in Human Hepatocellular Carcinoma. Cheng K, et al. Cell Physiol Biochem, 2017. PMID 28472789
  2. Aberrant methylation and downregulation of ZNF667-AS1 and ZNF667 promote the malignant progression of laryngeal squamous cell carcinoma. Meng W, et al. J Biomed Sci, 2019 Jan 26. PMID 30684967, Free PMC Article
  3. Effect of MIPU1 gene interference on biological behavior of U251 cell line. Liu M, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2020 Feb 28. PMID 32386033
  4. ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway. Wang W, et al. Int J Mol Med, 2022 Oct. PMID 36043524, Free PMC Article
  5. Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. Jiang L, et al. Biochem Biophys Res Commun, 2007 May 18. PMID 17397802

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway.
    Title: ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway.
  2. MicroRNA-23b-3p participates in steroid-induced osteonecrosis of the femoral head by suppressing ZNF667 expression.
    Title: MicroRNA-23b-3p participates in steroid-induced osteonecrosis of the femoral head by suppressing ZNF667 expression.
  3. Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma.
    Title: Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma.
  4. Down-regulation of MIPU1 can promote apoptosis while inhibit the proliferation, invasion, and migration of U251 cells
    Title: Effect of MIPU1 gene interference on biological behavior of U251 cell line.
  5. ZNF667-AS1 and ZNF667 are both down-regulated by hypermethylation, and they serve as tumor suppressor genes in LSCC. ZNF667-AS1 regulates the expression of ZNF667 in cis.
    Title: Aberrant methylation and downregulation of ZNF667-AS1 and ZNF667 promote the malignant progression of laryngeal squamous cell carcinoma.
  6. ZNF667 promote the cell proliferation, invasion and migration mainly via interference expression of Bcl-2 and BAX.
    Title: ZNF667 Serves as a Putative Oncogene in Human Hepatocellular Carcinoma.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14011, FLJ45518, DKFZp686O111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 667
Names
myocardial ischemic preconditioning upregulated 1 ortholog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321355.2 → NP_001308284.1  zinc finger protein 667 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC006116, AC013256, AC098795
    UniProtKB/TrEMBL
    Q5CZB4
    Conserved Domains (3) summary
    COG5048
    Location:84 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:444 → 464
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:456 → 481
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001321356.2 → NP_001308285.1  zinc finger protein 667 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC006116, AC013256, AC098795
    Consensus CDS
    CCDS12944.1
    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Related
    ENSP00000439402.1, ENST00000504904.8
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_022103.4 → NP_071386.3  zinc finger protein 667 isoform 1

    See identical proteins and their annotated locations for NP_071386.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC006116, AC013256, AC098795
    Consensus CDS
    CCDS12944.1
    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Related
    ENSP00000292069.5, ENST00000292069.10
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56439329..56478093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451637.2 → XP_024307405.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_024451642.2 → XP_024307410.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_047439212.1 → XP_047295168.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

  4. XM_024451646.2 → XP_024307414.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_024451647.2 → XP_024307415.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_024451644.2 → XP_024307412.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_024451643.2 → XP_024307411.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_024451645.2 → XP_024307413.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_011527208.3 → XP_011525510.1  zinc finger protein 667 isoform X1

    See identical proteins and their annotated locations for XP_011525510.1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. XM_047439211.1 → XP_047295167.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

  11. XM_047439208.1 → XP_047295164.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

  12. XM_024451641.2 → XP_024307409.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  13. XM_024451640.2 → XP_024307408.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  14. XM_047439209.1 → XP_047295165.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

  15. XM_047439210.1 → XP_047295166.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

  16. XM_047439207.1 → XP_047295163.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

  17. XM_024451638.2 → XP_024307406.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    Conserved Domains (3) summary
    smart00349
    Location:15 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59533762..59572529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321728.1 → XP_054177703.1  zinc finger protein 667 isoform X1

  2. XM_054321714.1 → XP_054177689.1  zinc finger protein 667 isoform X1

  3. XM_054321722.1 → XP_054177697.1  zinc finger protein 667 isoform X1

  4. XM_054321726.1 → XP_054177701.1  zinc finger protein 667 isoform X1

  5. XM_054321729.1 → XP_054177704.1  zinc finger protein 667 isoform X1

  6. XM_054321725.1 → XP_054177700.1  zinc finger protein 667 isoform X1

  7. XM_054321720.1 → XP_054177695.1  zinc finger protein 667 isoform X1

  8. XM_054321715.1 → XP_054177690.1  zinc finger protein 667 isoform X1

  9. XM_054321721.1 → XP_054177696.1  zinc finger protein 667 isoform X1

  10. XM_054321717.1 → XP_054177692.1  zinc finger protein 667 isoform X1

  11. XM_054321730.1 → XP_054177705.1  zinc finger protein 667 isoform X1

  12. XM_054321719.1 → XP_054177694.1  zinc finger protein 667 isoform X1

  13. XM_054321727.1 → XP_054177702.1  zinc finger protein 667 isoform X1

  14. XM_054321716.1 → XP_054177691.1  zinc finger protein 667 isoform X1

  15. XM_054321718.1 → XP_054177693.1  zinc finger protein 667 isoform X1

  16. XM_054321723.1 → XP_054177698.1  zinc finger protein 667 isoform X1

  17. XM_054321724.1 → XP_054177699.1  zinc finger protein 667 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HYK9.2 GenPept UniProtKB/Swiss-Prot:Q5HYK9

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