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Gmfb glia maturation factor, beta [ Mus musculus (house mouse) ]

Gene ID: 63985, updated on 2-Nov-2024

Summary

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Official Symbol
Gmfbprovided by MGI
Official Full Name
glia maturation factor, betaprovided by MGI
Primary source
MGI:MGI:1927133
See related
Ensembl:ENSMUSG00000062014 AllianceGenome:MGI:1927133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D14Ertd630e; 3110001H22Rik; 3110001O16Rik
Summary
Predicted to enable Arp2/3 complex binding activity. Acts upstream of or within learning and locomotory behavior. Predicted to be active in cortical actin cytoskeleton. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Orthologous to human GMFB (glia maturation factor beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 25.4), frontal lobe adult (RPKM 21.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Gmfb in Genome Data Viewer
Location:
14 C1; 14 24.32 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47045606..47059711, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46808149..46822259, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E752 Neighboring gene cyclin dependent kinase inhibitor 3 Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7306 Neighboring gene STARR-positive B cell enhancer ABC_E5430 Neighboring gene cell growth regulator with ring finger domain 1 Neighboring gene predicted gene, 34934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suppression of glia maturation factor expression prevents 1-methyl-4-phenylpyridinium (MPP⁺)-induced loss of mesencephalic dopaminergic neurons. Khan MM, et al. Neuroscience, 2014 Sep 26. PMID 25016212, Free PMC Article
  2. Diminished cytokine and chemokine expression in the central nervous system of GMF-deficient mice with experimental autoimmune encephalomyelitis. Zaheer A, et al. Brain Res, 2007 May 4. PMID 17316572, Free PMC Article
  3. Glia maturation factor modulates beta-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage. Zaheer A, et al. Brain Res, 2008 May 7. PMID 18395194, Free PMC Article
  4. Overexpression of glia maturation factor reinstates susceptibility to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in glia maturation factor deficient mice. Zaheer S, et al. Neurobiol Dis, 2010 Dec. PMID 20696246, Free PMC Article
  5. Glia maturation factor deficiency suppresses 1-methyl-4-phenylpyridinium-induced oxidative stress in astrocytes. Khan MM, et al. J Mol Neurosci, 2014 Aug. PMID 24430624, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer's Disease.
    Title: G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer's Disease.
  2. Glia Maturation Factor-beta Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals.
    Title: Glia Maturation Factor-β Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals.
  3. Neuroinflammation Mediated by Glia Maturation Factor Exacerbates Neuronal Injury in an in vitro Model of Traumatic Brain Injury.
    Title: Neuroinflammation Mediated by Glia Maturation Factor Exacerbates Neuronal Injury in an in vitro Model of Traumatic Brain Injury.
  4. Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain Injury.
    Title: Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain Injury.
  5. A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice.
    Title: A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice.
  6. Our studies show that the absence of mast cells and GMF reduce the expression of neuroinflammatory mediators in the brain.
    Title: Glia Maturation Factor and Mast Cell-Dependent Expression of Inflammatory Mediators and Proteinase Activated Receptor-2 in Neuroinflammation.
  7. This is the first study to demonstrate the expression of GMF-beta in reactive glial cells and its association with neuropathology in toxoplasmic encephalitis.
    Title: First description of enhanced expression of glia maturation factor-beta in experimental toxoplasmic encephalitis.
  8. GMF transgenic mice might be a novel mouse model of accelerated aging, due to the abnormal lamin A
    Title: Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation.
  9. Deficiency of glia maturation factor protects the dopaminergic neuron loss in a model of parkinsonism.
    Title: Absence of glia maturation factor protects dopaminergic neurons and improves motor behavior in mouse model of parkinsonism.
  10. The data suggest that debranching by GMFbeta plays an important role in branched actin regulation, lamellipodial dynamics, and directional migration.
    Title: GMFβ controls branched actin content and lamellipodial retraction in fibroblasts.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Arp2/3 complex binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament debranching IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament debranching IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glia maturation factor beta
Names
GMF-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022023.2 → NP_071306.2  glia maturation factor beta

    See identical proteins and their annotated locations for NP_071306.2

    Status: VALIDATED

    Source sequence(s)
    AC093043
    Consensus CDS
    CCDS36898.1
    UniProtKB/Swiss-Prot
    Q3UQX5, Q9CQI3, Q9ERL8
    UniProtKB/TrEMBL
    A0A2I3BPS1
    Related
    ENSMUSP00000107448.2, ENSMUST00000111817.8
    Conserved Domains (1) summary
    cd11283
    Location:9 → 130
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    47045606..47059711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247909.2 → XP_030103769.1  glia maturation factor beta isoform X1

    UniProtKB/TrEMBL
    A0A2I3BPS1, Q80X87
    Conserved Domains (1) summary
    cd11283
    Location:9 → 131
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

  2. XM_030247913.1 → XP_030103773.1  glia maturation factor beta isoform X3

    Conserved Domains (1) summary
    cd11283
    Location:1 → 97
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

  3. XM_036158778.1 → XP_036014671.1  glia maturation factor beta isoform X3

    Conserved Domains (1) summary
    cd11283
    Location:1 → 97
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

  4. XM_030247912.1 → XP_030103772.1  glia maturation factor beta isoform X3

    Conserved Domains (1) summary
    cd11283
    Location:1 → 97
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

  5. XM_030247911.1 → XP_030103771.1  glia maturation factor beta isoform X3

    Conserved Domains (1) summary
    cd11283
    Location:1 → 97
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

  6. XM_030247910.1 → XP_030103770.1  glia maturation factor beta isoform X2

    Conserved Domains (1) summary
    cd11283
    Location:1 → 98
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQI3.3 GenPept UniProtKB/Swiss-Prot:Q9CQI3

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