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SELPLG selectin P ligand [ Homo sapiens (human) ]

Gene ID: 6404, updated on 2-Nov-2024

Summary

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Official Symbol
SELPLGprovided by HGNC
Official Full Name
selectin P ligandprovided by HGNC
Primary source
HGNC:HGNC:10722
See related
Ensembl:ENSG00000110876 MIM:600738; AllianceGenome:HGNC:10722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLA; CD162; PSGL1; PSGL-1
Summary
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Expression
Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See SELPLG in Genome Data Viewer
Location:
12q24.11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108621895..108633894, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108596492..108608490, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109015671..109027670, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6969 Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108976096-108976273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108982554-108983282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108987423-108988089 Neighboring gene transmembrane protein 119 Neighboring gene Sharpr-MPRA regulatory region 9141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6971 Neighboring gene uncharacterized LOC105369968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4830 Neighboring gene microRNA 4496 Neighboring gene coronin 1C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6974 Neighboring gene RNA, U7 small nuclear 169 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment. Azab AK, et al. Blood, 2012 Feb 9. PMID 22096244, Free PMC Article
  2. SELPLG gene polymorphisms in relation to plasma SELPLG levels and coronary artery disease. Tregouet DA, et al. Ann Hum Genet, 2003 Nov. PMID 14641238
  3. Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1. Miyamura K, et al. J Gen Virol, 2011 Feb. PMID 20943886, Free PMC Article
  4. The variable number of tandem repeat polymorphism in the P-selectin glycoprotein ligand-1 gene is not associated with coronary heart disease. Bugert P, et al. J Mol Med (Berl), 2003 Aug. PMID 12879153
  5. Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection. Nishimura Y, et al. PLoS Pathog, 2010 Nov 4. PMID 21079683, Free PMC Article

See all (214) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Correlations of PSGL-1 VNTR polymorphism with the susceptibility to severe HFMD associated with EV-71 and the immune status after infection.
    Title: Correlations of PSGL-1 VNTR polymorphism with the susceptibility to severe HFMD associated with EV-71 and the immune status after infection.
  2. PSGL-1 decorated with sialyl Lewis[a/x] promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.
    Title: PSGL-1 decorated with sialyl Lewis(a/x) promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.
  3. PSGL-1 is an evolutionarily conserved antiviral restriction factor.
    Title: PSGL-1 is an evolutionarily conserved antiviral restriction factor.
  4. PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea.
    Title: PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea.
  5. PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages.
    Title: PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages.
  6. The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease.
    Title: The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease.
  7. Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation.
    Title: Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation.
  8. PSGL-1 attenuates early TCR signaling to suppress CD8[+] T cell progenitor differentiation and elicit terminal CD8[+] T cell exhaustion.
    Title: PSGL-1 attenuates early TCR signaling to suppress CD8(+) T cell progenitor differentiation and elicit terminal CD8(+) T cell exhaustion.
  9. Lnc-SELPLG-2:1 enhanced osteosarcoma oncogenesis via hsa-miR-10a-5p and the BTRC cascade.
    Title: Lnc-SELPLG-2:1 enhanced osteosarcoma oncogenesis via hsa-miR-10a-5p and the BTRC cascade.
  10. P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells.
    Title: P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells.
Submit: New GeneRIF Correction See all GeneRIFs (156)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Genome-wide association study of conduct disorder symptomatology.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CD3/CD28-activated primary CD4+ T cells downregulates plasma membrane expression of SELPLG (CD162, PSGL1) PubMed
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SELPLG PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Basic sequences in the cytoplasmic domains of PSGL-1, CD43, and CD44 are required for efficient association with HIV-1 Gag in HeLa cells PubMed
gag The highly basic region (HBR) of HIV-1 MA promotes Gag association with specific UDMs containing PSGL-1, CD43, and CD59 PubMed
gag HIV-1 Gag multimers associate with a specific subset of uropod-directed microdomains (UDMs) containing PSGL-1, CD43, and CD44 PubMed
gag HIV-1 Gag co-localizes with both uropod markers PSGL-1 and CD43 on the plasma membrane PubMed
Vpu vpu HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cellular response to interleukin-6 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in leukocyte adhesive activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in leukocyte migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in leukocyte tethering or rolling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukocyte tethering or rolling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in uropod IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
P-selectin glycoprotein ligand 1
Names
cutaneous lymphocyte-associated associated antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206609.2 → NP_001193538.1  P-selectin glycoprotein ligand 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007569, AC008119, AK298742, BC029782, CA427270, DC339004
    Consensus CDS
    CCDS55881.1
    UniProtKB/TrEMBL
    A0A0C4DFY0
    Related
    ENSP00000228463.6, ENST00000228463.7
    Conserved Domains (1) summary
    PRK10811
    Location:136 → 295
    rne; ribonuclease E; Reviewed

  2. NM_003006.4 → NP_002997.2  P-selectin glycoprotein ligand 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_002997.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008119, AK098315, AK225644
    Consensus CDS
    CCDS31895.2
    UniProtKB/Swiss-Prot
    A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q14242, Q6GTW7, Q8N7J7
    UniProtKB/TrEMBL
    A0A0C4DFY0
    Related
    ENSP00000447752.1, ENST00000550948.2
    Conserved Domains (1) summary
    PRK10811
    Location:120 → 279
    rne; ribonuclease E; Reviewed

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    108621895..108633894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    108596492..108608490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14242.1 GenPept UniProtKB/Swiss-Prot:Q14242

Gene LinkOut

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