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Hapln2 hyaluronan and proteoglycan link protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64057, updated on 2-Nov-2024

Summary

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Official Symbol
Hapln2provided by RGD
Official Full Name
hyaluronan and proteoglycan link protein 2provided by RGD
Primary source
RGD:621854
See related
EnsemblRapid:ENSRNOG00000018870 AllianceGenome:RGD:621854
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bral1
Summary
Predicted to enable hyaluronic acid binding activity. Predicted to be involved in nervous system development; positive regulation of neuroblast proliferation; and skeletal system development. Predicted to act upstream of or within establishment of blood-nerve barrier and extracellular matrix assembly. Predicted to be located in extracellular matrix and node of Ranvier. Predicted to be active in extracellular space; perineuronal net; and synapse. Orthologous to human HAPLN2 (hyaluronan and proteoglycan link protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 76.7) and Uterus (RPKM 2.8) See more
Orthologs
human mouse all
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Genomic context

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See Hapln2 in Genome Data Viewer
Location:
2q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175786767..175794515, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173488909..173496824, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187395104..187402076, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nestin Neighboring gene brevican Neighboring gene G patch domain containing 4 Neighboring gene NAD(P)HX epimerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Bral1: its role in diffusion barrier formation and conduction velocity in the CNS. Bekku Y, et al. J Neurosci, 2010 Feb 24. PMID 20181608, Free PMC Article
  2. Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems. Oohashi T, et al. Mol Cell Neurosci, 2002 Jan. PMID 11817897
  3. The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. Hirakawa S, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027579
  4. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of blood-nerve barrier IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of blood-nerve barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in glial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in node of Ranvier IEA
Inferred from Electronic Annotation
more info
  
located_in node of Ranvier ISO
Inferred from Sequence Orthology
more info
  
is_active_in perineuronal net IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hyaluronan and proteoglycan link protein 2
Names
brain link protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022285.2 → NP_071621.2  hyaluronan and proteoglycan link protein 2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q9ESM2
    UniProtKB/TrEMBL
    A6J644, G3V8G6
    Related
    ENSRNOP00000025624.4, ENSRNOT00000025624.9
    Conserved Domains (4) summary
    cd03518
    Location:149 → 242
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:251 → 338
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd00096
    Location:46 → 48
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:46 → 151
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    175786767..175794515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761209.4 → XP_008759431.1  hyaluronan and proteoglycan link protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008759431.1

    UniProtKB/Swiss-Prot
    Q9ESM2
    UniProtKB/TrEMBL
    A6J644, G3V8G6
    Conserved Domains (4) summary
    cd03518
    Location:149 → 242
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:251 → 338
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd00096
    Location:46 → 48
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:46 → 151
    Ig; Immunoglobulin domain

  2. XM_006232751.5 → XP_006232813.1  hyaluronan and proteoglycan link protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006232813.1

    UniProtKB/Swiss-Prot
    Q9ESM2
    UniProtKB/TrEMBL
    A6J644, G3V8G6
    Conserved Domains (4) summary
    cd03518
    Location:149 → 242
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:251 → 338
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd00096
    Location:46 → 48
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:46 → 151
    Ig; Immunoglobulin domain

  3. XM_017591067.3 → XP_017446556.1  hyaluronan and proteoglycan link protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9ESM2
    UniProtKB/TrEMBL
    A6J644, G3V8G6
    Conserved Domains (4) summary
    cd03518
    Location:149 → 242
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:251 → 338
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd00096
    Location:46 → 48
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:46 → 151
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESM2.1 GenPept UniProtKB/Swiss-Prot:Q9ESM2

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