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Popdc2 popeye domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 64082, updated on 2-Nov-2024

Summary

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Official Symbol
Popdc2provided by MGI
Official Full Name
popeye domain containing 2provided by MGI
Primary source
MGI:MGI:1930150
See related
Ensembl:ENSMUSG00000022803 AllianceGenome:MGI:1930150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pop2
Summary
This gene encodes a member of the Popeye domain containing family of membrane proteins. Proteins of this family contain three helical transmembrane domains and a conserved intracellular Popeye domain. In the adult mouse, this gene is expressed at high levels in cardiac myocytes, and mice deficient for this gene develop stress-induced cardiac pacemaker dysfunction. The protein binds to a two-pore domain potassium channel and recruits it to the plasma membrane. Cyclic adenosine monophosphate negatively regulates this interaction through the Popeye domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression
Biased expression in heart adult (RPKM 235.0), bladder adult (RPKM 61.2) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Popdc2 in Genome Data Viewer
Location:
16 B3; 16 26.79 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38182523..38198578)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38362161..38378216)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 91 Neighboring gene STARR-positive B cell enhancer ABC_E9163 Neighboring gene cytochrome c oxidase assembly protein 17, copper chaperone Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:38400095-38400248 Neighboring gene phospholipase A1 member A Neighboring gene STARR-positive B cell enhancer ABC_E8634 Neighboring gene STARR-seq mESC enhancer starr_40819 Neighboring gene STARR-seq mESC enhancer starr_40820 Neighboring gene predicted gene, 36333

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression pattern of Popdc2 during mouse embryogenesis and in the adult. Froese A, et al. Dev Dyn, 2008 Mar. PMID 18189275
  2. POPDC2 a novel susceptibility gene for conduction disorders. Rinné S, et al. J Mol Cell Cardiol, 2020 Aug. PMID 32535041
  3. The cAMP-binding Popdc proteins have a redundant function in the heart. Brand T, et al. Biochem Soc Trans, 2014 Apr. PMID 24646234, Free PMC Article
  4. Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking. Swan AH, et al. Acta Neuropathol Commun, 2023 Jan 9. PMID 36624536, Free PMC Article
  5. Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis. Dupays L, et al. Cell Rep, 2015 Oct 6. PMID 26411676, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POPDC2 a novel susceptibility gene for conduction disorders.
    Title: POPDC2 a novel susceptibility gene for conduction disorders.
  2. Sequential binding of MEIS1 and NKX2-5 on the Popdc2 gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.
    Title: Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis.
  3. Popdc1 and Popdc2 proteins interact with the potassium channel TREK-1, which leads to increased cell surface expression and enhanced current density
    Title: Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.
  4. Popdc2 is expressed in various muscle and nonmuscle cell types during embryonic development and in postnatal life
    Title: Expression pattern of Popdc2 during mouse embryogenesis and in the adult.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sinoatrial node cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in striated muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
popeye domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081984.2 → NP_001075453.1  popeye domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001075453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC064005, BY236921
    Consensus CDS
    CCDS37343.1
    UniProtKB/TrEMBL
    Q6P3F7
    Related
    ENSMUSP00000023494.7, ENSMUST00000023494.13
    Conserved Domains (1) summary
    pfam04831
    Location:26 → 251
    Popeye; Popeye protein conserved region

  2. NM_022318.3 → NP_071713.1  popeye domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_071713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and differs in the 3' UTR compared to variant (1). The encoded isoform (2) is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC064005, BY236921
    Consensus CDS
    CCDS37342.1
    UniProtKB/Swiss-Prot
    Q9ES82
    Related
    ENSMUSP00000110387.2, ENSMUST00000114739.2
    Conserved Domains (1) summary
    pfam04831
    Location:26 → 251
    Popeye; Popeye protein conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    38182523..38198578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522439.4 → XP_006522502.1  popeye domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    pfam04831
    Location:26 → 264
    Popeye; Popeye protein conserved region

  2. XM_006522438.4 → XP_006522501.1  popeye domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam04831
    Location:26 → 264
    Popeye; Popeye protein conserved region

  3. XM_030249226.1 → XP_030105086.1  popeye domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam04831
    Location:26 → 200
    Popeye; Popeye protein conserved region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES82.1 GenPept UniProtKB/Swiss-Prot:Q9ES82

Gene LinkOut

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