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Kcnk12 potassium two pore domain channel subfamily K member 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64119, updated on 14-Nov-2024

Summary

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Official Symbol
Kcnk12provided by RGD
Official Full Name
potassium two pore domain channel subfamily K member 12provided by RGD
Primary source
RGD:68940
See related
EnsemblRapid:ENSRNOG00000016110 AllianceGenome:RGD:68940
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
THIK-2
Summary
Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905828.1 and NW_007905829.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]
Orthologs
human mouse all
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Genomic context

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See Kcnk12 in Genome Data Viewer
Location:
6q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (12492609..12544250)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (6740147..6790664)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (11373917..11494459, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene F-box protein 11 Neighboring gene mutS homolog 6 Neighboring gene uncharacterized LOC134479271 Neighboring gene uncharacterized LOC120103460 Neighboring gene mutS homolog 2 Neighboring gene epithelial cell adhesion molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2. Renigunta V, et al. Pflugers Arch, 2014 Sep. PMID 24297522
  2. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. Rajan S, et al. J Biol Chem, 2001 Mar 9. PMID 11060316
  3. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. Theilig F, et al. Cell Physiol Biochem, 2008. PMID 18209473
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the characteristics of THIK-2 channels can be analysed in heterologous expression systems by using trafficking and/or gating mutants
    Title: Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2.
  2. THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
    Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
potassium channel subfamily K member 12
Names
potassium channel, subfamily K, member 12
potassium channel, two pore domain subfamily K, member 12
tandem pore domain halothane-inhibited potassium channel 2
tandem pore domain potassium channel THIK-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022292.2 → NP_071628.1  potassium channel subfamily K member 12

    See identical proteins and their annotated locations for NP_071628.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q9ERS1
    UniProtKB/TrEMBL
    A6H9C8
    Related
    ENSRNOP00000021570.1, ENSRNOT00000021570.4
    Conserved Domains (1) summary
    pfam07885
    Location:222 → 304
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    12492609..12544250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112871.2 → XP_038968799.1  potassium channel subfamily K member 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZT0
    Conserved Domains (1) summary
    pfam07885
    Location:313 → 395
    Ion_trans_2; Ion channel

  2. XM_039112873.2 → XP_038968801.1  potassium channel subfamily K member 12 isoform X2

    Conserved Domains (1) summary
    pfam07885
    Location:89 → 171
    Ion_trans_2; Ion channel
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERS1.1 GenPept UniProtKB/Swiss-Prot:Q9ERS1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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