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Iffo2 intermediate filament family orphan 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 641315, updated on 17-Aug-2024

Summary

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Official Symbol
Iffo2provided by RGD
Official Full Name
intermediate filament family orphan 2provided by RGD
Primary source
RGD:1624207
See related
EnsemblRapid:ENSRNOG00000071266 AllianceGenome:RGD:1624207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity and oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in intermediate filament. Predicted to be integral component of membrane. Orthologous to human IFFO2 (intermediate filament family orphan 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 64.1), Kidney (RPKM 53.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Iffo2 in Genome Data Viewer
Location:
5q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (157114089..157160135)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151830900..151876948)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (158042587..158083311)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ER membrane protein complex subunit 1 Neighboring gene ubiquitin protein ligase E3 component n-recognin 4 Neighboring gene transfer RNA valine (anticodon AAC) 3 Neighboring gene uncharacterized LOC134479043 Neighboring gene microRNA 6215 Neighboring gene aldehyde dehydrogenase 4 family, member A1 Neighboring gene taste 1 receptor member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-pyrroline-5-carboxylate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proline catabolic process to glutamate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intermediate filament family orphan 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134703.2 → NP_001128175.2  intermediate filament family orphan 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8L2R1U3
    Related
    ENSRNOP00000098376.2, ENSRNOT00000120750.2
    Conserved Domains (1) summary
    pfam00038
    Location:189 → 478
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    157114089..157160135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C6R4.1 GenPept UniProtKB/Swiss-Prot:P0C6R4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.