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Gosr2 golgi SNAP receptor complex member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64154, updated on 2-Nov-2024

Summary

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Official Symbol
Gosr2provided by RGD
Official Full Name
golgi SNAP receptor complex member 2provided by RGD
Primary source
RGD:62079
See related
EnsemblRapid:ENSRNOG00000003506 AllianceGenome:RGD:62079
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intra-Golgi vesicle-mediated transport and vesicle fusion. Predicted to act upstream of or within vesicle-mediated transport. Part of SNARE complex. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 6. Orthologous to human GOSR2 (golgi SNAP receptor complex member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 363.4), Testes (RPKM 172.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gosr2 in Genome Data Viewer
Location:
10q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (89085323..89105665, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88585291..88605642, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91735772..91756123, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693460 Neighboring gene lysozyme-like 6 Neighboring gene reprimo-like Neighboring gene mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction, pseudogene 1 Neighboring gene uncharacterized LOC120095298 Neighboring gene Wnt family member 9B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Magmas gene structure and evolution. Peng J, et al. In Silico Biol, 2005. PMID 15984936
  2. A SNARE involved in protein transport through the Golgi apparatus. Lowe SL, et al. Nature, 1997 Oct 23. PMID 9349823
  3. RNA interference-mediated silencing of the syntaxin 5 gene induces Golgi fragmentation but capable of transporting vesicles. Suga K, et al. FEBS Lett, 2005 Aug 15. PMID 16081076
  4. Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. Zhang T, et al. J Biol Chem, 2001 Jul 20. PMID 11323436
  5. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Hay JC, et al. Cell, 1997 Apr 4. PMID 9094723

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intra-Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Golgi SNAP receptor complex member 2
Names
27 kDa Golgi SNARE protein
membrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031685.2 → NP_113873.1  Golgi SNAP receptor complex member 2

    See identical proteins and their annotated locations for NP_113873.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061994
    UniProtKB/Swiss-Prot
    O08566, O35165, Q6GSW2
    UniProtKB/TrEMBL
    A0A8L2Q181, A6HJS5
    Related
    ENSRNOP00000005046.5, ENSRNOT00000005046.6
    Conserved Domains (1) summary
    cd15863
    Location:120 → 185
    SNARE_GS27; SNARE motif of GS27

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    89085323..89105665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597520.2 → XP_017453009.1  Golgi SNAP receptor complex member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AG32, A6HJS4
    Related
    ENSRNOP00000084049.2, ENSRNOT00000114651.2
    Conserved Domains (1) summary
    cl22856
    Location:113 → 138
    SNARE; SNARE motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35165.2 GenPept UniProtKB/Swiss-Prot:O35165

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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