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Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64156, updated on 2-Nov-2024

Summary

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Official Symbol
Uba52provided by RGD
Official Full Name
ubiquitin A-52 residue ribosomal protein fusion product 1provided by RGD
Primary source
RGD:68344
See related
EnsemblRapid:ENSRNOG00000090524 AllianceGenome:RGD:68344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ubb; Rps27a
Summary
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Involved in response to insecticide. Part of cytosolic large ribosomal subunit. Orthologous to human UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 2356.7), Heart (RPKM 2317.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uba52 in Genome Data Viewer
Location:
16p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18952583..18954780)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18918614..18920807)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20668925..20671127)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene elongation factor for RNA polymerase II Neighboring gene FKBP prolyl isomerase 8 Neighboring gene KxDL motif containing 1 Neighboring gene required for excision 1-B domain containing Neighboring gene cytokine receptor-like factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ubiquitin fusion proteins are overexpressed in colon cancer but not in gastric cancer. Barnard GF, et al. Biochim Biophys Acta, 1995 Dec 12. PMID 8541345
  2. The cDNA for the ubiquitin-52-amino-acid fusion protein from rat encodes a previously unidentified 60 S ribosomal subunit protein. Redman KL, et al. Biochem J, 1996 Apr 1. PMID 8670124, Free PMC Article
  3. Ubiquitin and ubiquitin-conjugated protein expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI). Yao X, et al. Brain Res, 2007 Nov 28. PMID 17936732
  4. The carboxyl extensions of two rat ubiquitin fusion proteins are ribosomal proteins S27a and L40. Chan YL, et al. Biochem Biophys Res Commun, 1995 Oct 13. PMID 7488009
  5. Post-translational processing of rat ribosomal proteins. Ubiquitous methylation of Lys22 within the zinc-finger motif of RL40 (carboxy-terminal extension protein 52) and tissue-specific methylation of Lys4 in RL29. Williamson NA, et al. Eur J Biochem, 1997 Jun 15. PMID 9219540

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death.
    Title: UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death.
  2. Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.
    Title: Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.
  3. Uba52 protein was restrictedly localized within the surface of the marginal cells of the stria vascularis of cochlea.
    Title: The localization of proteins encoded by CRYM, KIAA1199, UBA52, COL9A3, and COL9A1, genes highly expressed in the cochlea.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to insecticide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-ribosomal protein eL40 fusion protein
Names
60S ribosomal protein L40
CEP52
ubiquitin-60S ribosomal protein L40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031687.3 → NP_113875.1  ubiquitin-ribosomal protein eL40 fusion protein

    See identical proteins and their annotated locations for NP_113875.1

    Status: VALIDATED

    Source sequence(s)
    BC061544, BP480615, BP492585
    UniProtKB/Swiss-Prot
    P62986, P62989, Q63446
    UniProtKB/TrEMBL
    Q6P7R7
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79 → 126
    Ribosomal_L40e; Ribosomal L40e family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18952583..18954780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275684.1 → XP_063131754.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

  2. XM_008771146.4 → XP_008769368.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X3

    See identical proteins and their annotated locations for XP_008769368.1

    UniProtKB/Swiss-Prot
    P62986, P62989, Q63446
    UniProtKB/TrEMBL
    Q6P7R7
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79 → 126
    Ribosomal_L40e; Ribosomal L40e family

  3. XM_039094805.2 → XP_038950733.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X1

    Related
    ENSRNOP00000027073.4, ENSRNOT00000027073.8
    Conserved Domains (2) summary
    cd01803
    Location:42 → 117
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:120 → 167
    Ribosomal_L40e; Ribosomal L40e family

  4. XM_006252935.2 → XP_006252997.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X3

    See identical proteins and their annotated locations for XP_006252997.1

    UniProtKB/Swiss-Prot
    P62986, P62989, Q63446
    UniProtKB/TrEMBL
    Q6P7R7
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79 → 126
    Ribosomal_L40e; Ribosomal L40e family

  5. XM_063275685.1 → XP_063131755.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X3

    UniProtKB/Swiss-Prot
    P62986, P62989, Q63446
    UniProtKB/TrEMBL
    Q6P7R7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62986.2 GenPept UniProtKB/Swiss-Prot:P62986

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