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Mlst8 MTOR associated protein, LST8 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 64226, updated on 2-Nov-2024

Summary

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Official Symbol
Mlst8provided by RGD
Official Full Name
MTOR associated protein, LST8 homologprovided by RGD
Primary source
RGD:69242
See related
EnsemblRapid:ENSRNOG00000009667 AllianceGenome:RGD:69242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gbl
Summary
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within positive regulation of actin filament polymerization and positive regulation of peptidyl-tyrosine phosphorylation. Located in cytoplasm. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 67.5), Adrenal (RPKM 55.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mlst8 in Genome Data Viewer
Location:
10q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14002927..14008678, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13498377..13504128, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13839250..13845001, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene E4F transcription factor 1 Neighboring gene phosphoglycolate phosphatase Neighboring gene BRICHOS domain containing 5 Neighboring gene CASK interacting protein 1 Neighboring gene TNF receptor associated factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Insulin regulation of a novel WD-40 repeat protein in adipocytes. Rodgers BD, et al. J Endocrinol, 2001 Feb. PMID 11182770
  2. mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway. Kato H, et al. Cell Death Differ, 2012 Feb. PMID 21779001, Free PMC Article
  3. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Kim DH, et al. Mol Cell, 2003 Apr. PMID 12718876
  4. PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. Kamano Y, et al. FEBS Lett, 2013 Oct 11. PMID 24036451
  5. Molecular mechanisms of mTOR-mediated translational control. Ma XM, et al. Nat Rev Mol Cell Biol, 2009 May. PMID 19339977

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC114322

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in TORC1 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
target of rapamycin complex subunit LST8
Names
G beta-like protein
TORC subunit LST8
mammalian lethal with SEC13 protein 8
protein GbetaL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022404.2 → NP_071799.2  target of rapamycin complex subunit LST8

    See identical proteins and their annotated locations for NP_071799.2

    Status: VALIDATED

    Source sequence(s)
    BC097319, JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q4QRA0, Q9Z2K5
    UniProtKB/TrEMBL
    A0A8I5ZL90, A6HCT2
    Related
    ENSRNOP00000078598.1, ENSRNOT00000101517.2
    Conserved Domains (2) summary
    cd00200
    Location:14 → 297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:47 → 83
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14002927..14008678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597522.3 → XP_017453011.1  target of rapamycin complex subunit LST8 isoform X1

    UniProtKB/Swiss-Prot
    Q4QRA0, Q9Z2K5
    UniProtKB/TrEMBL
    A0A8I5ZL90, A6HCT2
    Conserved Domains (2) summary
    cd00200
    Location:14 → 297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:47 → 83
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2K5.2 GenPept UniProtKB/Swiss-Prot:Q9Z2K5

Gene LinkOut

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