U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 [ Homo sapiens (human) ]

Gene ID: 642517, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
AGAP9provided by HGNC
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 9provided by HGNC
Primary source
HGNC:HGNC:23463
See related
Ensembl:ENSG00000204172 AllianceGenome:HGNC:23463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGAP-9; CTGLF6; bA301J7.2
Summary
Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 15.8), skin (RPKM 15.2) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q11.22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (47501854..47523638, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (48393155..48414940, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (48215724..48237508)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47777655-47778618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:48276917-48277572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47168559-47169492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48257259-48257771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48255153-48256053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48254252-48255152 Neighboring gene BMS1P2-AGAP9 readthrough Neighboring gene annexin A8 Neighboring gene uncharacterized LOC124902421 Neighboring gene family with sequence similarity 25 member G Neighboring gene RNA, 5S ribosomal pseudogene 312

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. Liu Y, et al. Cancer Med, 2019 Feb. PMID 30652415, Free PMC Article
  2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Readthrough BMS1P2-AGAP9

Readthrough gene: BMS1P2-AGAP9, Included gene: BMS1P2

Homology

Clone Names

  • FLJ00312, FLJ39589, FLJ99065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
Names
centaurin-gamma-like family member 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190810.1 → NP_001177739.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9

    Status: VALIDATED

    Source sequence(s)
    BC171845, BC171847
    Consensus CDS
    CCDS73125.1
    UniProtKB/TrEMBL
    Q6ZMK7
    Related
    ENSP00000392206.2, ENST00000452145.6
    Conserved Domains (6) summary
    cd01250
    Location:280 → 444
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00023
    Location:623 → 643
    Ank; Ankyrin repeat
    pfam00169
    Location:283 → 442
    PH; PH domain
    pfam01412
    Location:466 → 580
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:596 → 643
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:591 → 621
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    47501854..47523638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    48393155..48414940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VTM2.2 GenPept UniProtKB/Swiss-Prot:Q5VTM2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous