U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SRSF3 serine and arginine rich splicing factor 3 [ Homo sapiens (human) ]

Gene ID: 6428, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
SRSF3provided by HGNC
Official Full Name
serine and arginine rich splicing factor 3provided by HGNC
Primary source
HGNC:HGNC:10785
See related
Ensembl:ENSG00000112081 MIM:603364; AllianceGenome:HGNC:10785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFRS3; SRp20
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 107.3), lymph node (RPKM 60.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SRSF3 in Genome Data Viewer
Location:
6p21.31-p21.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36594362..36605600)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36415006..36426242)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36562139..36573377)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901558 Neighboring gene serine/threonine kinase 38 Neighboring gene RNA, 7SL, cytoplasmic 748, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36514791-36515314 Neighboring gene MPRA-validated peak5783 silencer Neighboring gene MPRA-validated peak5784 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36544382-36545325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24430 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36561915-36562596 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564442-36564942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564943-36565443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567225-36567726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567727-36568226 Neighboring gene MPRA-validated peak5786 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24432 Neighboring gene microRNA 3925 Neighboring gene MPRA-validated peak5787 silencer Neighboring gene uncharacterized LOC105375038 Neighboring gene RNA, U1 small nuclear 88, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Ajiro M, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26704980, Free PMC Article
  2. Control of the papillomavirus early-to-late switch by differentially expressed SRp20. Jia R, et al. J Virol, 2009 Jan. PMID 18945760, Free PMC Article
  3. The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. Gonçalves V, et al. RNA, 2008 Dec. PMID 18952824, Free PMC Article
  4. Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer. He X, et al. Oncogene, 2011 Jan 20. PMID 20856201, Free PMC Article
  5. Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus. Fitzgerald KD, et al. PLoS Pathog, 2011 Jul. PMID 21779168, Free PMC Article

See all (299) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRSF3 suppresses RCC tumorigenesis and progression via regulating SP4 alternative splicing.
    Title: SRSF3 suppresses RCC tumorigenesis and progression via regulating SP4 alternative splicing.
  2. Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
    Title: Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
  3. Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells.
    Title: Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells.
  4. Intronic miR-6741-3p targets the oncogene SRSF3: Implications for oral squamous cell carcinoma pathogenesis.
    Title: Intronic miR-6741-3p targets the oncogene SRSF3: Implications for oral squamous cell carcinoma pathogenesis.
  5. Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
    Title: Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
  6. An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3.
    Title: An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3.
  7. Homeobox B9 Promotes Colon Cancer Progression by Targeting SRSF3.
    Title: Homeobox B9 Promotes Colon Cancer Progression by Targeting SRSF3.
  8. SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.
    Title: SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.
  9. Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.
    Title: Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.
  10. Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5.
    Title: Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5.
Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat SRSF3 (serine/arginine-rich splicing factor 3) inhibits HIV-1 Tat-mediated transactivation activity in HEK293 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables pre-mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables primary miRNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-RNA sequence-specific adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/arginine-rich splicing factor 3
Names
epididymis secretory sperm binding protein
pre-mRNA splicing factor SRp20
pre-mRNA-splicing factor SRP20
splicing factor, arginine/serine-rich 3
splicing factor, arginine/serine-rich, 20-kD

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003017.5 → NP_003008.1  serine/arginine-rich splicing factor 3

    See identical proteins and their annotated locations for NP_003008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding variant.
    Source sequence(s)
    Z85986
    Consensus CDS
    CCDS4823.1
    UniProtKB/Swiss-Prot
    B4E241, O08831, P23152, P84103, Q5R3K0
    UniProtKB/TrEMBL
    B2R6F3
    Related
    ENSP00000362820.5, ENST00000373715.11
    Conserved Domains (1) summary
    cd12645
    Location:6 → 86
    RRM_SRSF3; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 3 (SRSF3)

RNA

  1. NR_036610.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon in the 3' UTR compared to variant 1, making this transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this transcript is not thought to be protein-coding.
    Source sequence(s)
    AF107405, BM833102, DC398250, Z85986

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    36594362..36605600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    36415006..36426242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84103.1 GenPept UniProtKB/Swiss-Prot:P84103

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous