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Svs3a seminal vesicle secretory protein 3A [ Mus musculus (house mouse) ]

Gene ID: 64335, updated on 28-Oct-2024

Summary

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Official Symbol
Svs3aprovided by MGI
Official Full Name
seminal vesicle secretory protein 3Aprovided by MGI
Primary source
MGI:MGI:1927635
See related
Ensembl:ENSMUSG00000017003 AllianceGenome:MGI:1927635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Svp3; Svs3; Semg2; Svp-3; 9530026M05Rik
Summary
Predicted to enable protease binding activity and zinc ion binding activity. Acts upstream of or within mating plug formation. Located in extracellular region. Orthologous to human SEMG1 (semenogelin 1) and SEMG2 (semenogelin 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Svs3a in Genome Data Viewer
Location:
2 H3; 2 85.07 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164131187..164133420)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164289267..164291500)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene seminal vesicle secretory protein 3B Neighboring gene seminal vesicle secretory protein 4 Neighboring gene seminal vesicle secretory protein 6 Neighboring gene seminal vesicle secretory protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional preservation of duplicated pair for RSVS III gene in the REST locus of rat 3q42. Lin HJ, et al. Biochem Biophys Res Commun, 2005 Jan 14. PMID 15582586
  2. Localization of the transglutaminase cross-linking site in SVS III, a novel glycoprotein secreted from mouse seminal vesicle. Lin HJ, et al. J Biol Chem, 2002 Feb 1. PMID 11723121
  3. Syp-3, a third polymorphic locus for mouse seminal vesicle proteins. Moutier R, et al. Biochem Genet, 1983 Aug. PMID 6626148
  4. Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. Ulvsbäck M, et al. J Biol Chem, 1992 Sep 5. PMID 1517240
  5. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report the gene duplication of SVS III in both mouse and rat.
    Title: Functional preservation of duplicated pair for RSVS III gene in the REST locus of rat 3q42.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mating plug formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IC
Inferred by Curator
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
seminal vesicle secretory protein 3A
Names
SVS III
semenogelin II
seminal vesicle protein 3
seminal vesicle secretion 3 alpha
seminal vesicle secretion 3A
seminal vesicle secretory protein III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311114.1 → NP_001298043.1  seminal vesicle secretory protein 3A isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK020575, AL590429
    Consensus CDS
    CCDS79860.1
    UniProtKB/Swiss-Prot
    F2Z472
    Related
    ENSMUSP00000104995.2, ENSMUST00000109370.2

  2. NM_021363.2 → NP_067338.2  seminal vesicle secretory protein 3A isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK020575, BC131996, BY722061, DV048837
    Consensus CDS
    CCDS17030.1
    UniProtKB/Swiss-Prot
    F2Z467, F2Z472, Q8VI13, Q9JKD2
    Related
    ENSMUSP00000017147.8, ENSMUST00000017147.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164131187..164133420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F2Z472.1 GenPept UniProtKB/Swiss-Prot:F2Z472

Gene LinkOut

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