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LIPK lipase family member K [ Homo sapiens (human) ]

Gene ID: 643414, updated on 5-Mar-2024

Summary

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Official Symbol
LIPKprovided by HGNC
Official Full Name
lipase family member Kprovided by HGNC
Primary source
HGNC:HGNC:23444
See related
Ensembl:ENSG00000204021 MIM:613922; AllianceGenome:HGNC:23444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIPL2; bA186O14.2
Summary
Predicted to enable lipoprotein lipase activity. Predicted to be involved in cornification. Predicted to be located in extracellular region. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward skin (RPKM 5.3) See more
Orthologs
all
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Genomic context

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Location:
10q23.31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88706249..88752776)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89590236..89636775)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90466006..90512533)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase F, gastric type Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:90462586-90463435 Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, gamma pseudogene 1 Neighboring gene keratin 8 pseudogene 38 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:90518932-90520131 Neighboring gene lipase family member N Neighboring gene RCC1 and BTB domain containing protein 2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Large-scale identification of human genes implicated in epidermal barrier function. Toulza E, et al. Genome Biol, 2007. PMID 17562024, Free PMC Article
  2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipoprotein lipase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in cornification TAS
Traceable Author Statement
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lipase member K
Names
lipase K
lipase-like abhydrolase domain-containing protein 2
lipase-like, ab-hydrolase domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080518.2 → NP_001073987.1  lipase member K isoform 1 precursor

    See identical proteins and their annotated locations for NP_001073987.1

    Status: VALIDATED

    Source sequence(s)
    AL358532
    Consensus CDS
    CCDS44455.1
    UniProtKB/Swiss-Prot
    A7KIH8, Q5VXJ0
    Related
    ENSP00000383900.1, ENST00000404190.3
    Conserved Domains (3) summary
    PLN02872
    Location:11 → 390
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:35 → 97
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:79 → 226
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_001378091.1 → NP_001365020.1  lipase member K isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL358532
    Conserved Domains (1) summary
    PLN02872
    Location:11 → 357
    PLN02872; triacylglycerol lipase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    88706249..88752776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540075.2 → XP_011538377.1  lipase member K isoform X2

    Conserved Domains (3) summary
    PLN02872
    Location:20 → 399
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:44 → 106
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:88 → 235
    Abhydrolase_5; Alpha/beta hydrolase family

  2. XM_011540073.4 → XP_011538375.1  lipase member K isoform X1

    Conserved Domains (3) summary
    PLN02872
    Location:31 → 410
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:55 → 117
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:99 → 246
    Abhydrolase_5; Alpha/beta hydrolase family

  3. XM_017016545.2 → XP_016872034.1  lipase member K isoform X3

  4. XM_017016547.3 → XP_016872036.1  lipase member K isoform X5

  5. XM_017016546.3 → XP_016872035.1  lipase member K isoform X4

  6. XM_017016548.3 → XP_016872037.1  lipase member K isoform X6

  7. XM_011540082.2 → XP_011538384.1  lipase member K isoform X7

    Conserved Domains (1) summary
    PLN02872
    Location:7 → 256
    PLN02872; triacylglycerol lipase

RNA

  1. XR_001747183.3 RNA Sequence

  2. XR_001747184.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    89590236..89636775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366571.1 → XP_054222546.1  lipase member K isoform X2

  2. XM_054366570.1 → XP_054222545.1  lipase member K isoform X1

  3. XM_054366572.1 → XP_054222547.1  lipase member K isoform X3

  4. XM_054366574.1 → XP_054222549.1  lipase member K isoform X5

  5. XM_054366573.1 → XP_054222548.1  lipase member K isoform X4

  6. XM_054366575.1 → XP_054222550.1  lipase member K isoform X6

  7. XM_054366576.1 → XP_054222551.1  lipase member K isoform X7

RNA

  1. XR_008488249.1 RNA Sequence

  2. XR_008488250.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VXJ0.2 GenPept UniProtKB/Swiss-Prot:Q5VXJ0

Gene LinkOut

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