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Metap2 methionyl aminopeptidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64370, updated on 10-Jul-2024

Summary

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Official Symbol
Metap2provided by RGD
Official Full Name
methionyl aminopeptidase 2provided by RGD
Primary source
RGD:70995
See related
EnsemblRapid:ENSRNOG00000021881 AllianceGenome:RGD:70995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p67; Amp2; Mnpep
Summary
Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in N-terminal protein amino acid modification; peptidyl-methionine modification; and protein processing. Predicted to be located in cytosol and plasma membrane. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 375.2), Muscle (RPKM 306.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Metap2 in Genome Data Viewer
Location:
7q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30299433..30327477, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28412429..28440458, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (34762241..34789456, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479662 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene uncharacterized LOC120093556 Neighboring gene microRNA 331

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. p67/MetAP2 suppresses K-RasV12-mediated transformation of NIH3T3 mouse fibroblasts in culture and in athymic mice. Majumdar A, et al. Biochemistry, 2010 Nov 30. PMID 21033716
  2. High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas. Selvakumar P, et al. Clin Cancer Res, 2004 Apr 15. PMID 15102683
  3. Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase. Li X, et al. Biochem Biophys Res Commun, 1996 Oct 3. PMID 8858118
  4. Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67). Wu S, et al. J Biol Chem, 1993 May 25. PMID 8496145
  5. Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis. Kass D, et al. Am J Respir Cell Mol Biol, 2007 Aug. PMID 17446530

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables aminopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables initiator methionyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloexopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloexopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloexopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methionine aminopeptidase 2
Names
MAP 2
initiation factor 2 associated 67 kDa protein
initiation factor 2-associated 67 kDa glycoprotein
metAP 2
p67eIF2
peptidase M 2
NP_071984.2
XP_038935781.1
XP_038935782.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022539.2 → NP_071984.2  methionine aminopeptidase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P38062
    UniProtKB/TrEMBL
    Q5BKA1
    Related
    ENSRNOP00000032680.7, ENSRNOT00000030056.8
    Conserved Domains (1) summary
    PTZ00053
    Location:107 → 478
    PTZ00053; methionine aminopeptidase 2; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    30299433..30327477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079853.2 → XP_038935781.1  methionine aminopeptidase 2 isoform X1

    UniProtKB/Swiss-Prot
    P38062
    Related
    ENSRNOP00000087571.2, ENSRNOT00000110473.2
    Conserved Domains (1) summary
    PTZ00053
    Location:106 → 477
    PTZ00053; methionine aminopeptidase 2; Provisional

  2. XM_039079854.2 → XP_038935782.1  methionine aminopeptidase 2 isoform X2

    UniProtKB/Swiss-Prot
    P38062
    UniProtKB/TrEMBL
    F7FJ19, Q6IRK1
    Related
    ENSRNOP00000030415.5, ENSRNOT00000031571.8
    Conserved Domains (1) summary
    PTZ00053
    Location:71 → 442
    PTZ00053; methionine aminopeptidase 2; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38062.2 GenPept UniProtKB/Swiss-Prot:P38062

Gene LinkOut

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