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Timm8b translocase of inner mitochondrial membrane 8 homolog B [ Rattus norvegicus (Norway rat) ]

Gene ID: 64372, updated on 2-Nov-2024

Summary

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Official Symbol
Timm8bprovided by RGD
Official Full Name
translocase of inner mitochondrial membrane 8 homolog Bprovided by RGD
Primary source
RGD:619840
See related
AllianceGenome:RGD:619840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ddp2
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in protein transport. Predicted to be located in mitochondrion. Orthologous to human TIMM8B (translocase of inner mitochondrial membrane 8 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 1740.5), Muscle (RPKM 1543.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Timm8b in Genome Data Viewer
Location:
8q23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (59850737..59852117)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (50954350..50955730)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55037750..55039130)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene interleukin 18 Neighboring gene testis expressed 12 Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene NKAP domain containing 1 Neighboring gene PIH1 domain containing 2 Neighboring gene dihydrolipoamide S-acetyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
  2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
  3. Gene expression profiling of purified rat retinal ganglion cells. Farkas RH, et al. Invest Ophthalmol Vis Sci, 2004 Aug. PMID 15277470
  4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Pieragostino D, et al. Mol Biosyst, 2013 Jun. PMID 23580065
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim8 B
Names
deafness dystonia protein 2 homolog
small zinc finger-like protein DDP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022541.2 → NP_071986.1  mitochondrial import inner membrane translocase subunit Tim8 B

    See identical proteins and their annotated locations for NP_071986.1

    Status: VALIDATED

    Source sequence(s)
    AF196315, CF977529
    UniProtKB/Swiss-Prot
    P62078
    UniProtKB/TrEMBL
    A6J4E1
    Conserved Domains (1) summary
    pfam02953
    Location:16 → 74
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    59850737..59852117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62078.1 GenPept UniProtKB/Swiss-Prot:P62078

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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