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PGA4 pepsinogen A4 [ Homo sapiens (human) ]

Gene ID: 643847, updated on 5-Mar-2024

Summary

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Official Symbol
PGA4provided by HGNC
Official Full Name
pepsinogen A4provided by HGNC
Primary source
HGNC:HGNC:8886
See related
Ensembl:ENSG00000229183 MIM:169720; AllianceGenome:HGNC:8886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Expression
Restricted expression toward stomach (RPKM 23688.7) See more
Orthologs
all
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Genomic context

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Location:
11q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61222347..61231694)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61211336..61220690)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60989819..60999166)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60960971-60961472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60961473-60961972 Neighboring gene pepsinogen A3 Neighboring gene pepsinogen A5 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:61033788-61034987 Neighboring gene von Willebrand factor C and EGF domains Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61048939-61049860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61061839-61062541

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal structure of human pepsin and its complex with pepstatin. Fujinaga M, et al. Protein Sci, 1995 May. PMID 7663352, Free PMC Article
  2. Activation of human pepsinogens. Foltmann B. FEBS Lett, 1988 Dec 5. PMID 3197840
  3. Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family. Evers MP, et al. Genomics, 1989 Apr. PMID 2714789
  4. Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis. Terasawa T, et al. PLoS One, 2014. PMID 25314140, Free PMC Article
  5. The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China. Zhang XM, et al. BMC Gastroenterol, 2014 Jan 3. PMID 24383519, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ58952, FLJ77962

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in digestion IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in multivesicular body lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
pepsin A-4
Names
pepsinogen 4, group I (pepsinogen A)
pepsinogen-4
pregnancy-associated glycoprotein
NP_001073276.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079808.6 → NP_001073276.1  pepsin A-4 preproprotein

    See identical proteins and their annotated locations for NP_001073276.1

    Status: REVIEWED

    Source sequence(s)
    AP000437, AP003037
    Consensus CDS
    CCDS31575.1
    UniProtKB/Swiss-Prot
    P0DJD7
    UniProtKB/TrEMBL
    A0A1S5UZ02, B7ZW16
    Related
    ENSP00000367391.3, ENST00000378149.9
    Conserved Domains (2) summary
    cd05478
    Location:66 → 386
    pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals
    pfam07966
    Location:17 → 45
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    61222347..61231694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    61211336..61220690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DJD7.1 GenPept UniProtKB/Swiss-Prot:P0DJD7

Gene LinkOut

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