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ZDHHC6 zinc finger DHHC-type palmitoyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 64429, updated on 3-Apr-2024

Summary

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Official Symbol
ZDHHC6provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:19160
See related
Ensembl:ENSG00000023041 MIM:618715; AllianceGenome:HGNC:19160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC6; DHHC-6; ZNF376
Summary
Enables palmitoyltransferase activity. Involved in positive regulation of mitochondrial fusion and protein palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine (RPKM 19.0), duodenum (RPKM 17.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZDHHC6 in Genome Data Viewer
Location:
10q25.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (112424412..112447572, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (113315089..113338239, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (114184170..114207330, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2832 Neighboring gene microRNA 6715b Neighboring gene microRNA 6715a Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114135606-114136106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114136107-114136607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2834 Neighboring gene acyl-CoA synthetase long chain family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4066 Neighboring gene Sharpr-MPRA regulatory region 13267 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4067 Neighboring gene uncharacterized LOC124902503 Neighboring gene microRNA 4295 Neighboring gene Sharpr-MPRA regulatory region 921 Neighboring gene Sharpr-MPRA regulatory region 3692 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:114492107-114492608 Neighboring gene Sharpr-MPRA regulatory region 7283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114563987-114564486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114570610-114571310 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114571311-114572009 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114572010-114572709 Neighboring gene uncharacterized LOC103344931

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. Kim YC, et al. Nat Chem Biol, 2019 Sep. PMID 31427815
  2. Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer. Marciel MP, et al. Biol Trace Elem Res, 2019 Nov. PMID 31187393, Free PMC Article
  3. Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Yang W, et al. Mol Cell Proteomics, 2010 Jan. PMID 19801377, Free PMC Article
  4. RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase. Fairbank M, et al. FEBS Lett, 2012 Jul 30. PMID 22728137
  5. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. Abrami L, et al. Elife, 2017 Aug 15. PMID 28826475, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. human ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade.
    Title: Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade.
  2. DHHC6 knockdown using shRNA in stably transfected cell lines led to decreased expression of the IP3R and impaired IP3R-dependent Ca(2+) flux.
    Title: Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. Data show that palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain.
    Title: Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21952, FLJ30429

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-stearoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stearoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC6
Names
stearoyltransferase ZDHHC6
transmembrane protein H4
zinc finger DHHC domain-containing protein 6
zinc finger DHHC-type containing 6
zinc finger protein 376
NP_001290063.1
NP_001338011.1
NP_001338012.1
NP_001338013.1
NP_001338014.1
NP_001338015.1
NP_001350473.1
NP_001397995.1
NP_071939.1
XP_006718012.1
XP_011538393.1
XP_011538395.1
XP_011538397.1
XP_016872051.1
XP_016872052.1
XP_016872053.1
XP_016872055.1
XP_016872056.1
XP_016872057.1
XP_016872058.1
XP_047281609.1
XP_047281610.1
XP_047281611.1
XP_047281613.1
XP_047281614.1
XP_047281615.1
XP_047281616.1
XP_047281617.1
XP_054222573.1
XP_054222574.1
XP_054222575.1
XP_054222576.1
XP_054222577.1
XP_054222578.1
XP_054222579.1
XP_054222580.1
XP_054222581.1
XP_054222582.1
XP_054222583.1
XP_054222584.1
XP_054222585.1
XP_054222586.1
XP_054222587.1
XP_054222588.1
XP_054222589.1
XP_054222590.1
XP_054222591.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303134.2 → NP_001290063.1  palmitoyltransferase ZDHHC6 isoform 2

    See identical proteins and their annotated locations for NP_001290063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI695150, BC007213, BX647270, DA745043
    Consensus CDS
    CCDS76335.1
    UniProtKB/TrEMBL
    A0A804HJ80
    Related
    ENSP00000358412.3, ENST00000369404.3
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 237
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_001351082.3 → NP_001338011.1  palmitoyltransferase ZDHHC6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AC022018, AI695150, AK025605, BX647270, DA745043, DC354896
    Consensus CDS
    CCDS7574.1
    UniProtKB/Swiss-Prot
    D3DRB6, Q53G45, Q96IV7, Q9H605, Q9H6R6
    UniProtKB/TrEMBL
    A0A804HJ80
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase
    cl17036
    Location:317 → 394
    SH3; Src Homology 3 domain superfamily

  3. NM_001351083.2 → NP_001338012.1  palmitoyltransferase ZDHHC6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AI695150, AK025605, BX647270, DA936028
    Consensus CDS
    CCDS7574.1
    UniProtKB/Swiss-Prot
    D3DRB6, Q53G45, Q96IV7, Q9H605, Q9H6R6
    UniProtKB/TrEMBL
    A0A804HJ80
    Related
    ENSP00000507661.1, ENST00000683895.1
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase
    cl17036
    Location:317 → 394
    SH3; Src Homology 3 domain superfamily

  4. NM_001351084.2 → NP_001338013.1  palmitoyltransferase ZDHHC6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AI695150, AK025605, BX647270, DA621943, DA936028
    Consensus CDS
    CCDS7574.1
    UniProtKB/Swiss-Prot
    D3DRB6, Q53G45, Q96IV7, Q9H605, Q9H6R6
    UniProtKB/TrEMBL
    A0A804HJ80
    Related
    ENSP00000507009.1, ENST00000684507.1
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase
    cl17036
    Location:317 → 394
    SH3; Src Homology 3 domain superfamily

  5. NM_001351085.2 → NP_001338014.1  palmitoyltransferase ZDHHC6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AI695150, AK025605, BP378060, BX647270, DA745043
    Conserved Domains (2) summary
    cl17036
    Location:213 → 292
    SH3; Src Homology 3 domain superfamily
    cl19890
    Location:49 → 137
    DHHC; DHHC palmitoyltransferase

  6. NM_001351086.2 → NP_001338015.1  palmitoyltransferase ZDHHC6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AI695150, AK025605, BP378060, BX647270, DA745043, DB122344
    Conserved Domains (1) summary
    cl19890
    Location:52 → 133
    zf-DHHC; DHHC palmitoyltransferase

  7. NM_001363544.2 → NP_001350473.1  palmitoyltransferase ZDHHC6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC022018, AL157786
    Consensus CDS
    CCDS86144.1
    UniProtKB/TrEMBL
    A0A0D9SEX5, A0A804HL63
    Related
    ENSP00000507679.1, ENST00000682267.1
    Conserved Domains (1) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase

  8. NM_001411066.1 → NP_001397995.1  palmitoyltransferase ZDHHC6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC022018
    Consensus CDS
    CCDS91345.1
    UniProtKB/TrEMBL
    A0A804HJ40

  9. NM_022494.3 → NP_071939.1  palmitoyltransferase ZDHHC6 isoform 1

    See identical proteins and their annotated locations for NP_071939.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AI695150, AK025605, BX647270, DA745043
    Consensus CDS
    CCDS7574.1
    UniProtKB/Swiss-Prot
    D3DRB6, Q53G45, Q96IV7, Q9H605, Q9H6R6
    UniProtKB/TrEMBL
    A0A804HJ80
    Related
    ENSP00000358413.3, ENST00000369405.7
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase
    cl17036
    Location:317 → 394
    SH3; Src Homology 3 domain superfamily

RNA

  1. NR_147045.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022018, AI695150, AK025605, AW751101, BX647270, DA745043
    Related
    ENST00000684173.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    112424412..112447572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425653.1 → XP_047281609.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5

  2. XM_047425660.1 → XP_047281616.1  palmitoyltransferase ZDHHC6 isoform X9

  3. XM_017016566.3 → XP_016872055.1  palmitoyltransferase ZDHHC6 isoform X3

    UniProtKB/TrEMBL
    A0A804HL63

  4. XM_047425657.1 → XP_047281613.1  palmitoyltransferase ZDHHC6 isoform X6

  5. XM_011540091.3 → XP_011538393.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5, A0A804HL63
    Related
    ENSP00000508215.1, ENST00000683505.1
    Conserved Domains (1) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase

  6. XM_017016564.3 → XP_016872053.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5, A0A804HL63
    Related
    ENSP00000486105.1, ENST00000626395.2
    Conserved Domains (1) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase

  7. XM_047425654.1 → XP_047281610.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5
    Related
    ENSP00000508135.1, ENST00000682839.1

  8. XM_047425659.1 → XP_047281615.1  palmitoyltransferase ZDHHC6 isoform X8

  9. XM_017016563.3 → XP_016872052.1  palmitoyltransferase ZDHHC6 isoform X1

    UniProtKB/TrEMBL
    A0A804HJ80
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 237
    zf-DHHC; DHHC palmitoyltransferase

  10. XM_017016568.3 → XP_016872057.1  palmitoyltransferase ZDHHC6 isoform X8

    Conserved Domains (2) summary
    cl17036
    Location:213 → 292
    SH3; Src Homology 3 domain superfamily
    cl19890
    Location:49 → 137
    DHHC; DHHC palmitoyltransferase

  11. XM_017016567.3 → XP_016872056.1  palmitoyltransferase ZDHHC6 isoform X5

    UniProtKB/TrEMBL
    A0A804HJ80

  12. XM_011540095.4 → XP_011538397.1  palmitoyltransferase ZDHHC6 isoform X10

  13. XM_006717949.5 → XP_006718012.1  palmitoyltransferase ZDHHC6 isoform X4

    See identical proteins and their annotated locations for XP_006718012.1

    UniProtKB/TrEMBL
    A0A804HJ40, A0A804HJ80
    Related
    ENSP00000507345.1, ENST00000682195.1
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 188
    zf-DHHC; DHHC palmitoyltransferase
    cl17036
    Location:263 → 342
    SH3; Src Homology 3 domain superfamily

  14. XM_017016562.3 → XP_016872051.1  palmitoyltransferase ZDHHC6 isoform X1

    UniProtKB/TrEMBL
    A0A804HJ80
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 237
    zf-DHHC; DHHC palmitoyltransferase

  15. XM_047425661.1 → XP_047281617.1  palmitoyltransferase ZDHHC6 isoform X10

  16. XM_011540093.3 → XP_011538395.1  palmitoyltransferase ZDHHC6 isoform X8

    See identical proteins and their annotated locations for XP_011538395.1

    Conserved Domains (2) summary
    cl17036
    Location:213 → 292
    SH3; Src Homology 3 domain superfamily
    cl19890
    Location:49 → 137
    DHHC; DHHC palmitoyltransferase

  17. XM_047425655.1 → XP_047281611.1  palmitoyltransferase ZDHHC6 isoform X4

    UniProtKB/TrEMBL
    A0A804HJ40

  18. XM_017016569.2 → XP_016872058.1  palmitoyltransferase ZDHHC6 isoform X11

  19. XM_047425658.1 → XP_047281614.1  palmitoyltransferase ZDHHC6 isoform X7

RNA

  1. XR_007061983.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    113315089..113338239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366602.1 → XP_054222577.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5

  2. XM_054366613.1 → XP_054222588.1  palmitoyltransferase ZDHHC6 isoform X9

  3. XM_054366604.1 → XP_054222579.1  palmitoyltransferase ZDHHC6 isoform X3

  4. XM_054366600.1 → XP_054222575.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5

  5. XM_054366601.1 → XP_054222576.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5

  6. XM_054366608.1 → XP_054222583.1  palmitoyltransferase ZDHHC6 isoform X6

  7. XM_054366603.1 → XP_054222578.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5

  8. XM_054366612.1 → XP_054222587.1  palmitoyltransferase ZDHHC6 isoform X8

  9. XM_054366599.1 → XP_054222574.1  palmitoyltransferase ZDHHC6 isoform X1

  10. XM_054366610.1 → XP_054222585.1  palmitoyltransferase ZDHHC6 isoform X8

  11. XM_054366607.1 → XP_054222582.1  palmitoyltransferase ZDHHC6 isoform X5

  12. XM_054366614.1 → XP_054222589.1  palmitoyltransferase ZDHHC6 isoform X10

  13. XM_054366605.1 → XP_054222580.1  palmitoyltransferase ZDHHC6 isoform X4

    UniProtKB/TrEMBL
    A0A804HJ40

  14. XM_054366598.1 → XP_054222573.1  palmitoyltransferase ZDHHC6 isoform X1

  15. XM_054366615.1 → XP_054222590.1  palmitoyltransferase ZDHHC6 isoform X10

  16. XM_054366611.1 → XP_054222586.1  palmitoyltransferase ZDHHC6 isoform X8

  17. XM_054366606.1 → XP_054222581.1  palmitoyltransferase ZDHHC6 isoform X4

    UniProtKB/TrEMBL
    A0A804HJ40

  18. XM_054366616.1 → XP_054222591.1  palmitoyltransferase ZDHHC6 isoform X11

  19. XM_054366609.1 → XP_054222584.1  palmitoyltransferase ZDHHC6 isoform X7

RNA

  1. XR_008488252.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6R6.1 GenPept UniProtKB/Swiss-Prot:Q9H6R6

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