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St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64445, updated on 2-Nov-2024

Summary

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Official Symbol
St3gal3provided by RGD
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 3provided by RGD
Primary source
RGD:68414
See related
EnsemblRapid:ENSRNOG00000019843 AllianceGenome:RGD:68414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ST3N; Siat6; ST3GalIII; ST3Gal III
Summary
Predicted to enable beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process via lactosylceramide and protein glycosylation. Predicted to be located in Golgi cisterna membrane and extracellular region. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 12 and developmental and epileptic encephalopathy 15. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 46.2), Liver (RPKM 34.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St3gal3 in Genome Data Viewer
Location:
5q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (136755780..136958081, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131470348..131670794, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (136765309..136965642, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene importin 13 Neighboring gene uncharacterized LOC120102961 Neighboring gene artemin Neighboring gene uncharacterized LOC120102959 Neighboring gene uncharacterized LOC120102960 Neighboring gene uncharacterized LOC134486979 Neighboring gene lysine demethylase 4A Neighboring gene protein tyrosine phosphatase, receptor type, F Neighboring gene uncharacterized LOC102553423

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo. Pérez-Garay M, et al. PLoS One, 2010 Sep 1. PMID 20824144, Free PMC Article
  2. Primary structure of Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase determined by mass spectrometry sequence analysis and molecular cloning. Evidence for a protein motif in the sialyltransferase gene family. Wen DX, et al. J Biol Chem, 1992 Oct 15. PMID 1400416
  3. Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Kono M, et al. Glycobiology, 1997 Jun. PMID 9184827
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. St3gal3 modulates pancreatic cancer cell motility and adhesion and enhances metastatic potential.
    Title: alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process via lactosylceramide IEA
Inferred from Electronic Annotation
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Names
N-acetyllacosaminide alpha 2,3-sialyltransferase
N-acetyllactosaminide alpha-2,3-sialyltransferase
beta-galactoside alpha-2,3-sialyltransferase 3
gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase
sialyltransferase (N-acetyllacosaminide alpha 23-sialyltransferase)
sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
sialyltransferase 6(N-acetyllacosaminide alpha 23-sialyltransferase)
XP_006238777.1
XP_006238778.1
XP_038966633.1
XP_038966634.1
XP_063144417.1
XP_063144418.1
XP_063144419.1
XP_063144420.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429992.1 → NP_001416921.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JZG3, F1LM32

  2. NM_001430000.1 → NP_001416929.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6GDQ1

  3. NM_031697.2 → NP_113885.2  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JZG3, F1LM32
    Related
    ENSRNOP00000053685.2, ENSRNOT00000056842.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    136755780..136958081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238715.4 → XP_006238777.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:106 → 370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_063288350.1 → XP_063144420.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X4

    Related
    ENSRNOP00000086704.1, ENSRNOT00000097514.2

  3. XM_006238716.4 → XP_006238778.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X2

    Related
    ENSRNOP00000086133.1, ENSRNOT00000106433.2
    Conserved Domains (1) summary
    pfam00777
    Location:90 → 354
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_039110706.2 → XP_038966634.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:14 → 278
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_039110705.2 → XP_038966633.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:14 → 278
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  6. XM_063288347.1 → XP_063144417.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

  7. XM_063288349.1 → XP_063144419.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

  8. XM_063288348.1 → XP_063144418.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02734.1 GenPept UniProtKB/Swiss-Prot:Q02734

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