Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Entpd2provided by RGD
Official Full Name: ectonucleoside triphosphate diphosphohydrolase 2provided by RGD
Primary source: RGD:69266
See related: EnsemblRapid:ENSRNOG00000013102 AllianceGenome:RGD:69266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd39l1; NTPDase2
Summary: Enables ADP phosphatase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to auditory stimulus. Located in cell body; cell projection membrane; and cell surface. Biomarker of hypertension. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 61.9), Heart (RPKM 46.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28611722..28617237)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8213575..8219094)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2617795..2623818)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation.
Title: Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation.
ADP-mediated Modulation of Intracellular Calcium Responses in Chromaffin Cells: The Role of Ectonucleoside Triphosphate Diphosphohydrolase 2 on Rat Adrenal Medulla Function.
Title: ADP-mediated Modulation of Intracellular Calcium Responses in Chromaffin Cells: The Role of Ectonucleoside Triphosphate Diphosphohydrolase 2 on Rat Adrenal Medulla Function.
Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro.
Title: Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro.
At the transcriptional level, extracellular ATP upregulated expression of NTPDase1, NTPDase2, NPP2, and eN, while, at translational and functional levels, these were paralleled only by the induction of NTPDase2 and ecto-5'-nucleotidase.
Title: Extracellular ATP Selectively Upregulates Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 and Ecto-5'-Nucleotidase by Rat Cortical Astrocytes In Vitro.
Apo and complex structures of the rat NTPDase2 extracellular domain and Legionella pneumophila NTPDase1.
Title: Crystallographic snapshots along the reaction pathway of nucleoside triphosphate diphosphohydrolases.
two ENTPD isoforms, ENTPD-1 and -2, are expressed in adult rat ventricular CFs
Title: Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts.
NTPDase2 overexpression modulates pro-inflammatory cytokine production and platelet reactivity.
Title: Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury.
ATP acts in an autocrine manner to promote its own release and that of dopamine, an action that is controlled by the level of E-NTPDase1/CD39 expression
Title: The expression level of ecto-NTP diphosphohydrolase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons.
Modulation of ATP, ADP and AMP hydrolysis suggests that they operate during EAE and might represent the basis of novel therapeutic strategies in immune-mediated diseases, such as MS.
Title: Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis.
Selective NTPDase2 expression modulates in vivo rat glioma growth.
Title: Selective NTPDase2 expression modulates in vivo rat glioma growth.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleoside diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoside triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-6	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in nucleoside diphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet activation	ISO Inferred from Sequence Orthology more info
involved_in purine ribonucleoside diphosphate catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine ribonucleoside diphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to auditory stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ectonucleoside triphosphate diphosphohydrolase 2

Names: CD39 antigen-like 1; NTPDase 2; ecto-ATP diphosphohydrolase 2; ecto-ATPDase 2; ecto-ATPase 2; nucleoside triphosphate diphosphohydrolase 2; testicular ecto-ATPase

XP_006233706.1

EC 3.6.1.-

XP_017447512.1

EC 3.6.1.-

XP_017447513.1

EC 3.6.1.-

XP_038961718.1

EC 3.6.1.-

XP_063140588.1

EC 3.6.1.-

XP_063140589.1

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429439.1 → NP_001416368.1 ectonucleoside triphosphate diphosphohydrolase 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_172030.2 → NP_742027.2 ectonucleoside triphosphate diphosphohydrolase 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

Q5RJP4

Related

ENSRNOP00000086303.2, ENSRNOT00000094013.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

28611722..28617237

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233644.5 → XP_006233706.1 ectonucleoside triphosphate diphosphohydrolase 2 isoform X2

UniProtKB/TrEMBL

A0A8I6AFG9, F1M7N2

Related

ENSRNOP00000017829.3, ENSRNOT00000017829.6

Conserved Domains (1) summary

cl17037
Location:39 → 453

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
XM_017592023.3 → XP_017447512.1 ectonucleoside triphosphate diphosphohydrolase 2 isoform X1

UniProtKB/TrEMBL

A0A8I6AFG9
XM_039105790.2 → XP_038961718.1 ectonucleoside triphosphate diphosphohydrolase 2 isoform X3

UniProtKB/Swiss-Prot

O35795, Q9JHY5, Q9WVE7

Conserved Domains (1) summary

cl17037
Location:39 → 476

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
XM_017592024.3 → XP_017447513.1 ectonucleoside triphosphate diphosphohydrolase 2 isoform X4

Related

ENSRNOP00000101840.1, ENSRNOT00000167123.1
XM_063284518.1 → XP_063140588.1 ectonucleoside triphosphate diphosphohydrolase 2 isoform X5
XM_063284519.1 → XP_063140589.1 ectonucleoside triphosphate diphosphohydrolase 2 isoform X6