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P4ha1 prolyl 4-hydroxylase subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64475, updated on 2-Nov-2024

Summary

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Official Symbol
P4ha1provided by RGD
Official Full Name
prolyl 4-hydroxylase subunit alpha 1provided by RGD
Primary source
RGD:621000
See related
EnsemblRapid:ENSRNOG00000050655 AllianceGenome:RGD:621000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PHalphaI
Summary
Predicted to enable identical protein binding activity and procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to act upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in mitochondrion. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 265.1), Lung (RPKM 252.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See P4ha1 in Genome Data Viewer
Location:
20q11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (27784696..27895785)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (27302046..27352098)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28920616..28972576)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene septin 10 Neighboring gene sosondowah ankyrin repeat domain family member C Neighboring gene small nuclear ribonucleoprotein D2-like Neighboring gene U7 small nuclear RNA Neighboring gene phospholipase A2, group XIIB Neighboring gene oncoprotein induced transcript 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of the 5'-flanking region of the rat P4Halpha gene encoding the prolyl 4-hydroxylase alpha(I) subunit. Takahashi S, et al. Biochim Biophys Acta, 2002 Apr 12. PMID 11997102
  2. Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells. Takahashi Y, et al. J Biol Chem, 2000 May 12. PMID 10799490
  3. The complete cDNA derived sequence of the rat prolyl 4-hydroxylase alpha subunit. Hopkinson I, et al. Gene, 1994 Nov 18. PMID 7959029
  4. The structural motifs for substrate binding and dimerization of the α subunit of collagen prolyl 4-hydroxylase. Anantharajan J, et al. Structure, 2013 Dec 3. PMID 24207127
  5. Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice. Holster T, et al. J Biol Chem, 2007 Jan 26. PMID 17135260

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables procollagen-proline 4-dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables procollagen-proline 4-dioxygenase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of procollagen-proline 4-dioxygenase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
prolyl 4-hydroxylase subunit alpha-1
Names
4-PH alpha-1
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I
procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
prolyl 4-hydroxylase alpha subunit
prolyl 4-hydroxylase, alpha polypeptide I
NP_742059.2
XP_006256486.1
XP_006256487.1
XP_063135563.1
XP_063135564.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172062.3 → NP_742059.2  prolyl 4-hydroxylase subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_742059.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    P54001, Q6AZ74
    UniProtKB/TrEMBL
    A0A8L2QWJ8, A6K3U6
    Related
    ENSRNOP00000064405.3, ENSRNOT00000070897.3
    Conserved Domains (2) summary
    smart00702
    Location:345 → 518
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:25 → 112
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    27784696..27895785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279494.1 → XP_063135564.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

  2. XM_006256425.4 → XP_006256487.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_006256487.1

    UniProtKB/TrEMBL
    A0A8I6ASU1, A0A8L2QWJ8, A6K3U5
    Related
    ENSRNOP00000096608.1, ENSRNOT00000117090.2
    Conserved Domains (2) summary
    smart00702
    Location:345 → 518
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:25 → 112
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  3. XM_063279493.1 → XP_063135563.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASU1, A6K3U5

  4. XM_006256424.5 → XP_006256486.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

    See identical proteins and their annotated locations for XP_006256486.1

    UniProtKB/Swiss-Prot
    P54001, Q6AZ74
    UniProtKB/TrEMBL
    A0A8L2QWJ8, A6K3U6
    Conserved Domains (2) summary
    smart00702
    Location:345 → 518
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:25 → 112
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54001.2 GenPept UniProtKB/Swiss-Prot:P54001

Gene LinkOut

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