U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mfn2 mitofusin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64476, updated on 2-Nov-2024

Summary

Symbol
Mfn2provided by RGD
Full Name
mitofusin 2provided by RGD
Primary source
RGD:628843
See related
EnsemblRapid:ENSRNOG00000046424 AllianceGenome:RGD:628843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HSG
Summary
Enables several functions, including GTP binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including negative regulation of organelle organization; positive regulation of steroid hormone secretion; and regulation of reactive oxygen species biosynthetic process. Located in cytosol and mitochondrial outer membrane. Used to study carotid stenosis. Biomarker of several diseases, including artery disease (multiple); obesity; prediabetes syndrome; steatotic liver disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: GeneIDs: 64476 and 100911485 are annotated independently on Rnor_6.0 but may be redundant loci. [09 Feb 2015]
Expression
Biased expression in Heart (RPKM 743.7), Muscle (RPKM 606.6) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mfn2 in Genome Data Viewer
Location:
5q36
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163587463..163617363, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158304285..158335502, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164684244..164715414, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 933 Neighboring gene migration and invasion inhibitory protein Neighboring gene uncharacterized LOC134487036 Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proteoglycan binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aerobic respiration IEA
Inferred from Electronic Annotation
more info
 
involved_in aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in aerobic respiration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in blastocyst formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blastocyst formation ISO
Inferred from Sequence Orthology
more info
 
involved_in camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to L-glutamate IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to ionizing radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to low-density lipoprotein particle stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to mercaptoethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to testosterone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in intracellular distribution of mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mitochondrial calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrial membrane organization IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrion localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion localization IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrion localization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of D-glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of estradiol secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of progesterone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to phagophore assembly site IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein localization to phagophore assembly site ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to D-galactose IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to L-arginine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to axon injury IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to flavonoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypobaric hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to muscle activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in type 2 mitophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in type 2 mitophagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitofusin-2
Names
hypertension-related protein
mitochondrial transmembrane GTPase FZO1A
mitofusin-2-like
transmembrane GTPase MFN2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429964.1NP_001416893.1  mitofusin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A9N3, Q6IRL2
  2. NM_001429965.1NP_001416894.1  mitofusin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A9N3, Q6IRL2
  3. NM_001429966.1NP_001416895.1  mitofusin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A9N3, Q6IRL2
  4. NM_001429967.1NP_001416896.1  mitofusin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A9N3, Q6IRL2
  5. NM_001429968.1NP_001416897.1  mitofusin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A9N3, Q6IRL2
  6. NM_001429969.1NP_001416898.1  mitofusin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A9N3, Q6IRL2
  7. NM_001429970.1NP_001416899.1  mitofusin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A9N3, Q6IRL2
  8. NM_130894.5NP_570964.4  mitofusin-2

    See identical proteins and their annotated locations for NP_570964.4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    O09013, Q8R500
    UniProtKB/TrEMBL
    D4A9N3, Q6IRL2
    Conserved Domains (2) summary
    cd09912
    Location:97349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595754
    Fzo_mitofusin; fzo-like conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    163587463..163617363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764288.4XP_008762510.1  mitofusin-2 isoform X1

    Related
    ENSRNOP00000052539.3, ENSRNOT00000055680.5
    Conserved Domains (2) summary
    cd09912
    Location:97349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595754
    Fzo_mitofusin; fzo-like conserved region
  2. XM_063288356.1XP_063144426.1  mitofusin-2 isoform X1