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Ilkap ILK associated serine/threonine phosphatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 64538, updated on 14-Nov-2024

Summary

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Official Symbol
Ilkapprovided by RGD
Official Full Name
ILK associated serine/threonine phosphataseprovided by RGD
Primary source
RGD:620128
See related
EnsemblRapid:ENSRNOG00000020115 AllianceGenome:RGD:620128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation and regulation of nuclear cell cycle DNA replication. Predicted to be located in cytoplasm. Orthologous to human ILKAP (ILK associated serine/threonine phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 121.1), Adrenal (RPKM 104.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ilkap in Genome Data Viewer
Location:
9q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99413981..99436262, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (91966440..91988791, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98514599..98536586, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 30 Neighboring gene erythroferrone Neighboring gene uncharacterized LOC100912214 Neighboring gene uncharacterized LOC134480412 Neighboring gene hes family bHLH transcription factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C
    Title: Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS140 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of nuclear cell cycle DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin-linked kinase-associated serine/threonine phosphatase 2C
Names
PP2Cdelta
protein phosphatase 2C
NP_072128.2
XP_038940097.1
XP_038940098.1
XP_063123756.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022606.2 → NP_072128.2  integrin-linked kinase-associated serine/threonine phosphatase 2C

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q6P6U8, Q9Z1Z6
    UniProtKB/TrEMBL
    A0A0G2JSS1, A6JQR2
    Related
    ENSRNOP00000027295.4, ENSRNOT00000027295.7
    Conserved Domains (1) summary
    cd00143
    Location:108 → 390
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    99413981..99436262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084170.2 → XP_038940098.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

    UniProtKB/TrEMBL
    A6JQR3
    Conserved Domains (1) summary
    cd00143
    Location:1 → 270
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  2. XM_039084169.2 → XP_038940097.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

    UniProtKB/TrEMBL
    A6JQR3
    Conserved Domains (1) summary
    cd00143
    Location:1 → 270
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  3. XM_063267686.1 → XP_063123756.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X1

    UniProtKB/TrEMBL
    A0A8I6GBB0
    Related
    ENSRNOP00000083940.1, ENSRNOT00000119384.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1Z6.1 GenPept UniProtKB/Swiss-Prot:Q9Z1Z6

Gene LinkOut

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