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Tspan4 tetraspanin 4 [ Mus musculus (house mouse) ]

Gene ID: 64540, updated on 2-Nov-2024

Summary

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Official Symbol
Tspan4provided by MGI
Official Full Name
tetraspanin 4provided by MGI
Primary source
MGI:MGI:1928097
See related
Ensembl:ENSMUSG00000025511 AllianceGenome:MGI:1928097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NAG-2; Tm4sf7; Tspan-4; D130042I01Rik
Summary
Predicted to enable antigen binding activity and integrin binding activity. Acts upstream of or within mitocytosis and regulation of mitochondrial membrane potential. Located in migrasome. Is expressed in several structures, including gut; jaw; rib cage; urinary system; and viscerocranium. Orthologous to human TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in ovary adult (RPKM 100.6), adrenal adult (RPKM 68.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Tspan4 in Genome Data Viewer
Location:
7 F5; 7 86.83 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141055194..141073340)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141475236..141493427)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10575 Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene CD151 antigen Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene chitinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_20492 Neighboring gene STARR-seq mESC enhancer starr_20493 Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene STARR-positive B cell enhancer ABC_E2855 Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression. Zheng Y, et al. Cell Adh Migr, 2023 Dec. PMID 36513632, Free PMC Article
  2. Identification of a mouse orthologue of the CED-6 gene of Caenorhabditis elegans. Banerjee H, et al. Plasmid, 2003 Jan. PMID 12583998
  3. Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii. Wylin T, et al. Eur J Biochem, 1998 Dec 1. PMID 9874197
  4. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Jiao H, et al. Cell, 2021 May 27. PMID 34048705
  5. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. Tachibana I, et al. J Biol Chem, 1997 Nov 14. PMID 9360996

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression.
    Title: TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Gene trapped (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC102386

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mitocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in migrasome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetraspanin-4
Names
novel antigen 2
tetraspan TM4SF
transmembrane 4 superfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252588.2 → NP_001239517.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_001239517.1

    Status: VALIDATED

    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS22018.1
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    Q4FJW7
    Related
    ENSMUSP00000113085.2, ENSMUST00000117634.2
    Conserved Domains (2) summary
    cd03165
    Location:105 → 202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9 → 226
    Tetraspannin; Tetraspanin family

  2. NM_001403355.1 → NP_001390284.1  tetraspanin-4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC158224
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    Q4FJW7

  3. NM_001403356.1 → NP_001390285.1  tetraspanin-4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC158224
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    Q4FJW7

  4. NM_001403357.1 → NP_001390286.1  tetraspanin-4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC158224
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    Q4FJW7

  5. NM_001403358.1 → NP_001390287.1  tetraspanin-4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158224
    UniProtKB/TrEMBL
    A0A668KLD1
    Related
    ENSMUSP00000159235.2, ENSMUST00000239217.2

  6. NM_053082.4 → NP_444312.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_444312.1

    Status: VALIDATED

    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS22018.1
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    Q4FJW7
    Related
    ENSMUSP00000026585.8, ENSMUST00000026585.14
    Conserved Domains (2) summary
    cd03165
    Location:105 → 202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9 → 226
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141055194..141073340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153326.1 → XP_036009219.1  tetraspanin-4 isoform X3

    Conserved Domains (1) summary
    cd03165
    Location:41 → 138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

  2. XM_036153327.1 → XP_036009220.1  tetraspanin-4 isoform X3

    Conserved Domains (1) summary
    cd03165
    Location:41 → 138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCK3.1 GenPept UniProtKB/Swiss-Prot:Q9DCK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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