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MT1HL1 metallothionein 1H like 1 [ Homo sapiens (human) ]

Gene ID: 645745, updated on 2-Nov-2024

Summary

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Official Symbol
MT1HL1provided by HGNC
Official Full Name
metallothionein 1H like 1provided by HGNC
Primary source
HGNC:HGNC:31864
See related
Ensembl:ENSG00000244020 AllianceGenome:HGNC:31864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT1P2
Summary
This gene is a retrotransposed gene, compared to MT1H (GeneID:4496). This retrogene is transcribed. It retains a full-length CDS, and is assumed to be translated. Compared to the MT1H product, this protein product differs at three internal amino acids, two of which are at metal-binding sites. [provided by RefSeq, Mar 2013]
Orthologs
all
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Genomic context

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See MT1HL1 in Genome Data Viewer
Location:
1q43
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (237004103..237004441, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (236415116..236415454, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (237167403..237167741, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904563 Neighboring gene uncharacterized LOC107985368 Neighboring gene VISTA enhancer hs2137 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:237173080-237174075 Neighboring gene VISTA enhancer hs2138 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:237179824-237180353 Neighboring gene MPRA-validated peak789 silencer Neighboring gene ribosomal protein L35 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:237238747-237239412 Neighboring gene ryanodine receptor 2 Neighboring gene RN7SK pseudogene 195 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:237451188-237452387 Neighboring gene microRNA 4428

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
metallothionein 1H-like protein 1
Names
MT-1H-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276687.2 → NP_001263616.1  metallothionein 1H-like protein 1

    See identical proteins and their annotated locations for NP_001263616.1

    Status: VALIDATED

    Source sequence(s)
    AF333388, AL359259
    Consensus CDS
    CCDS31068.1
    UniProtKB/Swiss-Prot
    P0DM35
    Related
    ENSP00000476141.1, ENST00000464121.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    237004103..237004441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    236415116..236415454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_007037.2: Suppressed sequence

    Description
    NG_007037.2: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein and is not a pseudogene.

  2. NM_001039954.2: Suppressed sequence

    Description
    NM_001039954.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DM35.1 GenPept UniProtKB/Swiss-Prot:P0DM35

Gene LinkOut

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