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Nmi N-myc (and STAT) interactor [ Mus musculus (house mouse) ]

Gene ID: 64685, updated on 28-Oct-2024

Summary

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Official Symbol
Nmiprovided by MGI
Official Full Name
N-myc (and STAT) interactorprovided by MGI
Primary source
MGI:MGI:1928368
See related
Ensembl:ENSMUSG00000026946 AllianceGenome:MGI:1928368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity. Involved in positive regulation of inflammatory response; response to virus; and toll-like receptor 4 signaling pathway. Acts upstream of or within negative regulation of innate immune response; negative regulation of type I interferon production; and positive regulation of protein K48-linked ubiquitination. Located in extracellular space. Is expressed in genitourinary system; limb; and retina. Orthologous to human NMI (N-myc and STAT interactor). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 5.8), large intestine adult (RPKM 5.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Nmi in Genome Data Viewer
Location:
2 C1.1; 2 29.98 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (51838517..51863241, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (51948498..51973489, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13495 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene STARR-seq mESC enhancer starr_04475 Neighboring gene tumor necrosis factor alpha induced protein 6 Neighboring gene STARR-seq mESC enhancer starr_04477 Neighboring gene replication timing regulatory factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. N-Myc and STAT Interactor is an Endometriosis Suppressor. Park Y, et al. Int J Mol Sci, 2024 Jul 26. PMID 39125716, Free PMC Article
  2. Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors. Pruitt HC, et al. Oncogene, 2018 Mar. PMID 29326438, Free PMC Article
  3. IFP35 family proteins promote neuroinflammation and multiple sclerosis. Jing X, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34362845, Free PMC Article
  4. Nmi interacts with Hsp105β and enhances the Hsp105β-mediated Hsp70 expression. Saito Y, et al. Exp Cell Res, 2014 Sep 10. PMID 25088258
  5. NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis. Hu H, et al. Mol Carcinog, 2024 Feb. PMID 37846815

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-Myc and STAT Interactor is an Endometriosis Suppressor.
    Title: N-Myc and STAT Interactor is an Endometriosis Suppressor.
  2. NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
    Title: NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
  3. IFP35 family proteins promote neuroinflammation and multiple sclerosis.
    Title: IFP35 family proteins promote neuroinflammation and multiple sclerosis.
  4. NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21.
    Title: NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21.
  5. Nmi has a distinct role in the differentiation process of mammary luminal epithelial cell compartment and developmental aberrations resulting from Nmi absence contribute to metastasis.
    Title: Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.
  6. Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways.
    Title: NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
  7. These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7
    Title: Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage activation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in macrophage activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of type I interferon production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N-myc-interactor
Names
N-mcy (and STAT) interactor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141948.2 → NP_001135420.1  N-myc-interactor isoform a

    See identical proteins and their annotated locations for NP_001135420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL929026
    Consensus CDS
    CCDS16031.1
    UniProtKB/Swiss-Prot
    O35309, Q99M49
    UniProtKB/TrEMBL
    Q3UJ82, Q4FJP2
    Related
    ENSMUSP00000108325.3, ENSMUST00000112705.9
    Conserved Domains (2) summary
    pfam07334
    Location:30 → 105
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:204 → 292
    NID; Nmi/IFP 35 domain (NID)

  2. NM_001141949.2 → NP_001135421.1  N-myc-interactor isoform a

    See identical proteins and their annotated locations for NP_001135421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL929026
    Consensus CDS
    CCDS16031.1
    UniProtKB/Swiss-Prot
    O35309, Q99M49
    UniProtKB/TrEMBL
    Q3UJ82, Q4FJP2
    Related
    ENSMUSP00000120647.2, ENSMUST00000145481.8
    Conserved Domains (2) summary
    pfam07334
    Location:30 → 105
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:204 → 292
    NID; Nmi/IFP 35 domain (NID)

  3. NM_001421887.1 → NP_001408816.1  N-myc-interactor isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL929026
    UniProtKB/Swiss-Prot
    O35309, Q99M49
    UniProtKB/TrEMBL
    Q3UJ82

  4. NM_001421888.1 → NP_001408817.1  N-myc-interactor isoform b

    Status: VALIDATED

    Source sequence(s)
    AL929026

  5. NM_001421889.1 → NP_001408818.1  N-myc-interactor isoform c

    Status: VALIDATED

    Source sequence(s)
    AL929026

  6. NM_001421890.1 → NP_001408819.1  N-myc-interactor isoform c

    Status: VALIDATED

    Source sequence(s)
    AL929026

  7. NM_001421891.1 → NP_001408820.1  N-myc-interactor isoform c

    Status: VALIDATED

    Source sequence(s)
    AL929026

  8. NM_019401.3 → NP_062274.1  N-myc-interactor isoform a

    See identical proteins and their annotated locations for NP_062274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL929026
    Consensus CDS
    CCDS16031.1
    UniProtKB/Swiss-Prot
    O35309, Q99M49
    UniProtKB/TrEMBL
    Q3UJ82, Q4FJP2
    Related
    ENSMUSP00000028314.3, ENSMUST00000028314.9
    Conserved Domains (2) summary
    pfam07334
    Location:30 → 105
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:204 → 292
    NID; Nmi/IFP 35 domain (NID)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    51838517..51863241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35309.1 GenPept UniProtKB/Swiss-Prot:O35309

Gene LinkOut

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