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SMYD3 SET and MYND domain containing 3 [ Homo sapiens (human) ]

Gene ID: 64754, updated on 2-Nov-2024

Summary

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Official Symbol
SMYD3provided by HGNC
Official Full Name
SET and MYND domain containing 3provided by HGNC
Primary source
HGNC:HGNC:15513
See related
Ensembl:ENSG00000185420 MIM:608783; AllianceGenome:HGNC:15513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KMT3E; ZMYND1; ZNFN3A1; bA74P14.1
Summary
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in thyroid (RPKM 1.8), brain (RPKM 1.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SMYD3 in Genome Data Viewer
Location:
1q44
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (245749347..246507279, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (245170078..245930104, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (245912649..246670581, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 26B Neighboring gene uncharacterized LOC124904571 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:245746285-245747484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245769345-245770175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245774720-245775220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245775221-245775721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245786008-245786527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245811797-245812310 Neighboring gene uncharacterized LOC105373265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245874319-245874820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245874821-245875320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245878266-245878766 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:245926173-245926700 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245938698-245939538 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245937857-245938697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245979520-245980135 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245980136-245980750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246016290-246016790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246016791-246017291 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:246032999-246034198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246111472-246111972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:246226795-246227321 Neighboring gene NANOG hESC enhancer GRCh37_chr1:246228833-246229369 Neighboring gene Sharpr-MPRA regulatory region 4643 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246273855-246274354 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246273353-246273854 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:246302792-246303991 Neighboring gene CRISPRi-validated SMYD3 hub enhancer Neighboring gene CRISPRi-validated SMYD3 non-hub enhancer Neighboring gene CRISPR perturbation-validated SMYD3 cis-regulatory element TAD4.SE2.HS8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2030 Neighboring gene SMYD3 antisense RNA 1 Neighboring gene CRISPR perturbation-validated SMYD3 cis-regulatory element TAD4.SE2.HS10 Neighboring gene uncharacterized LOC124904573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:246383465-246384417 Neighboring gene RNA, U6 small nuclear 1283, pseudogene Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 5 Neighboring gene VISTA enhancer hs2070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246487577-246488097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:246518331-246518956 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:246533672-246533878 Neighboring gene SMYD3 intronic transcript 1 Neighboring gene MPRA-validated peak812 silencer Neighboring gene Sharpr-MPRA regulatory region 15017 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246591613-246592114 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246592115-246592614 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:246612672-246613232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246669532-246670032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246670033-246670533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2034 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:246671208-246671440 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:246679947-246680127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246701627-246702127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2855 Neighboring gene long intergenic non-protein coding RNA 1743 Neighboring gene transcription factor B2, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Advances of histone methyltransferase SMYD3 in tumors]. Dong S, et al. Zhongguo Fei Ai Za Zhi, 2014 Sep 20. PMID 25248712, Free PMC Article
  2. SMYD3: a regulator of epigenetic and signaling pathways in cancer. Bernard BJ, et al. Clin Epigenetics, 2021 Feb 26. PMID 33637115, Free PMC Article
  3. Structural and functional profiling of the human histone methyltransferase SMYD3. Foreman KW, et al. PLoS One, 2011. PMID 21779408, Free PMC Article
  4. SMYD3 overexpression indicates poor prognosis and promotes cell proliferation, migration and invasion in non‑small cell lung cancer. Li J, et al. Int J Oncol, 2020 Sep. PMID 32705243, Free PMC Article
  5. Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Van Aller GS, et al. Epigenetics, 2012 Apr. PMID 22419068, Free PMC Article

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma.
    Title: THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma.
  2. SMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation.
    Title: SMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation.
  3. The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback.
    Title: The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback.
  4. SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck.
    Title: SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck.
  5. Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription.
    Title: Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription.
  6. SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation.
    Title: SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation.
  7. SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells.
    Title: SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells.
  8. SMYD3 regulates the abnormal proliferation of non-small-cell lung cancer cells via the H3K4me3/ANO1 axis.
    Title: SMYD3 regulates the abnormal proliferation of non-small-cell lung cancer cells via the H3K4me3/ANO1 axis.
  9. SMYD3 promotes aerobic glycolysis in diffuse large B-cell lymphoma via H3K4me3-mediated PKM2 transcription.
    Title: SMYD3 promotes aerobic glycolysis in diffuse large B-cell lymphoma via H3K4me3-mediated PKM2 transcription.
  10. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.
    Title: SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.
Submit: New GeneRIF Correction See all GeneRIFs (95)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21080, KIAA0504, MGC104324

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II complex binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 dimethyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K4 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in myotube cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase SMYD3
Names
SET and MYND domain-containing protein 3
zinc finger MYND domain-containing protein 1
zinc finger protein, subfamily 3A (MYND domain containing), 1
zinc finger, MYND domain containing 1
NP_001161212.1
NP_001362891.1
NP_001362892.1
NP_001362894.1
NP_001362895.1
NP_073580.1
XP_011542556.1
XP_011542559.1
XP_011542561.1
XP_011542563.1
XP_016857583.1
XP_024304904.1
XP_024304909.1
XP_024304917.1
XP_024304930.1
XP_047283975.1
XP_047283976.1
XP_047283977.1
XP_047283978.1
XP_054194247.1
XP_054194248.1
XP_054194249.1
XP_054194250.1
XP_054194251.1
XP_054194252.1
XP_054194253.1
XP_054194254.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167740.2 → NP_001161212.1  histone-lysine N-methyltransferase SMYD3 isoform 1

    See identical proteins and their annotated locations for NP_001161212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB057595, BI916760, BP231249
    Consensus CDS
    CCDS53486.1
    UniProtKB/Swiss-Prot
    A8K0P0, B1AN38, Q86TL8, Q8N5Z6, Q96AI5, Q9H7B4
    Related
    ENSP00000419184.2, ENST00000490107.6
    Conserved Domains (2) summary
    pfam00856
    Location:201 → 239
    SET; SET domain
    pfam01753
    Location:49 → 87
    zf-MYND; MYND finger

  2. NM_001375962.1 → NP_001362891.1  histone-lysine N-methyltransferase SMYD3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL356583, AL358859, AL445468, AL512412
    Conserved Domains (2) summary
    pfam01753
    Location:49 → 87
    zf-MYND; MYND finger
    cl40432
    Location:5 → 234
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  3. NM_001375963.1 → NP_001362892.1  histone-lysine N-methyltransferase SMYD3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL358859, AL445468, AL512412
    Consensus CDS
    CCDS31083.1
    Conserved Domains (2) summary
    pfam01753
    Location:1 → 28
    zf-MYND; MYND finger
    cd19203
    Location:39 → 209
    SET_SMYD3; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins

  4. NM_001375965.1 → NP_001362894.1  histone-lysine N-methyltransferase SMYD3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL445468, AL512412
    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46
    Conserved Domains (1) summary
    cl40432
    Location:1 → 79
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  5. NM_001375966.1 → NP_001362895.1  histone-lysine N-methyltransferase SMYD3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL445468, AL512412
    Conserved Domains (1) summary
    cl40432
    Location:9 → 76
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  6. NM_022743.3 → NP_073580.1  histone-lysine N-methyltransferase SMYD3 isoform 2

    See identical proteins and their annotated locations for NP_073580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK024733, AL356583, AL445468, AW173130
    Consensus CDS
    CCDS31083.1
    UniProtKB/Swiss-Prot
    Q9H7B4
    Related
    ENSP00000487434.1, ENST00000630181.2
    Conserved Domains (2) summary
    pfam01753
    Location:1 → 28
    zf-MYND; MYND finger
    cd19203
    Location:39 → 209
    SET_SMYD3; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    245749347..246507279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428020.1 → XP_047283976.1  histone-lysine N-methyltransferase SMYD3 isoform X2

  2. XM_024449136.2 → XP_024304904.1  histone-lysine N-methyltransferase SMYD3 isoform X2

    Conserved Domains (2) summary
    pfam01753
    Location:1 → 28
    zf-MYND; MYND finger
    cd19203
    Location:39 → 209
    SET_SMYD3; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins

  3. XM_047428021.1 → XP_047283977.1  histone-lysine N-methyltransferase SMYD3 isoform X2

  4. XM_047428019.1 → XP_047283975.1  histone-lysine N-methyltransferase SMYD3 isoform X1

  5. XM_017002094.3 → XP_016857583.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46
    Conserved Domains (1) summary
    cl40432
    Location:1 → 79
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  6. XM_024449162.2 → XP_024304930.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46
    Conserved Domains (1) summary
    cl40432
    Location:1 → 79
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  7. XM_047428022.1 → XP_047283978.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46

  8. XM_011544261.4 → XP_011542563.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    See identical proteins and their annotated locations for XP_011542563.1

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46
    Related
    ENST00000470510.5
    Conserved Domains (1) summary
    cl40432
    Location:1 → 79
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  9. XM_024449149.2 → XP_024304917.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46
    Conserved Domains (1) summary
    cl40432
    Location:1 → 79
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  10. XM_011544254.3 → XP_011542556.1  histone-lysine N-methyltransferase SMYD3 isoform X3

    Conserved Domains (1) summary
    pfam00856
    Location:59 → 97
    SET; SET domain

  11. XM_011544259.4 → XP_011542561.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    See identical proteins and their annotated locations for XP_011542561.1

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46
    Conserved Domains (1) summary
    cl40432
    Location:1 → 79
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  12. XM_024449141.2 → XP_024304909.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46
    Conserved Domains (1) summary
    cl40432
    Location:1 → 79
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  13. XM_011544257.2 → XP_011542559.1  histone-lysine N-methyltransferase SMYD3 isoform X4

    See identical proteins and their annotated locations for XP_011542559.1

    UniProtKB/Swiss-Prot
    Q9H7B4
    Conserved Domains (1) summary
    pfam00856
    Location:31 → 69
    SET; SET domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    245170078..245930104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338273.1 → XP_054194248.1  histone-lysine N-methyltransferase SMYD3 isoform X2

  2. XM_054338274.1 → XP_054194249.1  histone-lysine N-methyltransferase SMYD3 isoform X2

  3. XM_054338275.1 → XP_054194250.1  histone-lysine N-methyltransferase SMYD3 isoform X2

  4. XM_054338272.1 → XP_054194247.1  histone-lysine N-methyltransferase SMYD3 isoform X1

  5. XM_054338277.1 → XP_054194252.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46

  6. XM_054338278.1 → XP_054194253.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46

  7. XM_054338279.1 → XP_054194254.1  histone-lysine N-methyltransferase SMYD3 isoform X5

    UniProtKB/TrEMBL
    A0A024R5P8, B3KN46

  8. XM_054338276.1 → XP_054194251.1  histone-lysine N-methyltransferase SMYD3 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H7B4.4 GenPept UniProtKB/Swiss-Prot:Q9H7B4

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